1. To introduce basic concepts of organic synthesis:
In fact one synthesis uses the following as carbon sources:
– a paper operation involving an imagined cleavage of a bond (yielding ‘synthons’) to suggest a method and possible SM’s for making the bond, ultimately leading to possible SM’s for the overall synthesis.
And illustrate their use in synthesis.
In planning a synthetic strategy, apart from devising a means of constructing the carbon skeleton with the required functionality as above, there are other subtle factors, which we must address.
Thieme E-Journals - Synthesis / Abstract
It is not clear from this however, how the chemistry might be done! Therefore just being given the starting materials is not sufficient to help plan a synthesis.
Note the importance of CCBFR.
Wittig Synthesis of trans-9-(2-phenylethenyl) - Yumpu
We will illustrate this approach with examples, starting with synthesis of benzene derivatives. Starting point is usually fairly obvious – simple benzene derivatives or perhaps benzene itself.
[2,3]-Wittig Sigmatropic Rearrangements in Organic Synthesis
"The Wittig Reaction", Maercker, A. 1965, , 270. "Cycloalkenes by Intramolecular Wittig Reaction," Beeker, K. B. 1980,, 1717. "The Wittig Olefination Reaction of Carbonyl Compounds Other than Aldehydes and Ketones," Murphy, P. J. 1988, , 1. "The Wittig Olefination Reaction and Modifications Involving Phosphoryl-stabilized Carbanions. Stereochemistry, Mechanism, and Selected Synthetic Aspects," Maryanoff, B. E.; Reitz, A. B. 1989, , 863. "Synthesis of Heterocycles by the aza-Wittig Reaction," Gusar, N.I. 1991, , 146. "Stereochemistry and mechanism in the Wittig reaction," Vedejs, E.; Peterson, M. J. 1994, , 1. "Recent Synthetic Applications of the Non-Classical Wittig Reaction," Murphy, P. J.; Lee, S. E. 1999, 3049-66.