All about protein: What is it and how much do you need?

Interestingly, a single bout of exercise stimulates protein synthesis within 2-4 hours after the workout which may remain elevated for up to 24 hours (Rasmussen and Phillips, 2003).

01/03/2012 · Abstract Muscle protein synthesis ..

T1 - Protein-leucine fed dose effects on muscle protein synthesis after endurance exercise

Human muscle protein synthesis and breakdown during …

We evaluated the effects of transdermal testosterone administration for 3 wk on plasma FFA and VLDL-TG and VLDL-apoB-100 release into plasma, plasma lipid concentrations, and muscle protein synthesis in obese, premenopausal women. Testosterone treatment resulted in plasma testosterone concentrations that were approximately seven times greater than before treatment, but comparable to those in women with hyperandrogenemia due to PCOS (, ), although lower than the normal range for eugonadal men (). The approximately sevenfold increase in testosterone availability did not affect plasma FFA availability, hepatic VLDL-TG and VLDL-apoB-100 secretion rates, or plasma lipoprotein particle concentrations and particle sizes, except for a small (~10%) decrease in HDL particle and cholesterol concentrations, but robustly increased the muscle protein FSR. These findings indicate that testosterone is a potent skeletal muscle protein anabolic agent, but not an important regulator of plasma lipid kinetics; hyperandrogenemia is, therefore, most likely not responsible for the greater plasma TG concentration in men () and women with hyperandrogenemia/PCOS (, ) compared with healthy premenopausal women.

Myofibrillar muscle protein synthesis rates subsequent …

“Acute effects of resistance exercise on muscle protein synthesis rate in young and elderly men and women.” American Journal of Physiology 265: E210-E214.


Muscle protein synthesis response to exercise training …

Men and women with hyperandrogenemia have a more proatherogenic plasma lipid profile [e.g., greater triglyceride (TG) and total and low-density lipoprotein-cholesterol and lower high-density lipoprotein-cholesterol concentrations] than healthy premenopausal women. Furthermore, castration of male rats markedly reduces testosterone availability below normal and decreases plasma TG concentration, and testosterone replacement reverses this effect. Testosterone is, therefore, thought to be an important regulator of plasma lipid homeostasis. However, little is known about the effect of testosterone on plasma TG concentration and kinetics. Furthermore, testosterone is a potent skeletal muscle protein anabolic agent in men, but its effect on muscle protein turnover in women is unknown. We measured plasma lipid concentrations, hepatic very low density lipoprotein (VLDL)-TG and VLDL-apolipoprotein B-100 secretion rates, and the muscle protein fractional synthesis rate in 10 obese women before and after trandermal testosterone (1.25 g of 1% AndroGel daily) treatment for 3 wk. Serum total and free testosterone concentrations increased (P P P > 0.05); the muscle protein fractional synthesis rate, however, increased by ~45% (P

It is Muscle Protein Fractional Synthetic Rate

GH and IGF-1 play a dominant role in the regulation of protein metabolism; GH and T are required for protein maintenance; and IGF-1 levels are positively correlated with muscle protein synthesis rates, specifically myofibrillar protein (actin and myosin filaments) and myosin heavy chain synthesis (part of the myosin containing cross-bridges) (Waters, Baumgartner & Garry 2000).

No major sex differences in muscle protein synthesis …

These findings suggest that older men and women retain the ability to increase the rate of muscle protein synthesis in response to acute and long-term progressive resistance training.

Regulation of muscle protein degradation, not synthesis, ..

In addition, Yarasheski and others (1999) reported that 3 months of supervised progressive resistance training increased the rate of muscle protein synthesis by approximately 50% in seventeen frail 76 to 92 year old men and women.

Is Muscle Protein Synthesis the Same as Muscle Growth?

It is suggested that the new, popular periodization models of exercise training, which include light, moderate and high intensity training phases, satisfactorily overload the different muscle fiber types of the body while also providing sufficient rest for protein synthesis to occur.