FayUric acid in pregnancy and preeclampsia: an alternative ..
Uric Acid in Pregnancy and Preeclampsia: An Alternative Hypothesis.
Diuretics are first-line agents to be used in management of essential hypertension prior to conception and, based on their apparent safety, they may be continued during pregnancy alone or in combination with other agents especially in women more likely to have salt-responsive hypertension . Concerns regarding volume contraction leading to limited fetal growth have not been supported in studies . Mild volume contraction, however, may lead to hyperuricemia and in doing so invalidate serum uric acid levels as a laboratory marker that may assist in the diagnosis of superimposed preeclampsia. The adverse effects are mainly due to fluid, electrolytes, and solute disturbances.
Uric acid in pregnancy and preeclampsia: An alternative hypothesis.
Epidemiological characteristics of preeclampsia such as its uniqueness to humans and an increased incidence of preeclampsia in multiple pregnancies, increased body mass index, renal and hypertensive disease all have uric acid as their common denominator.