Depending on the amount of truncation, ..

If an unselected sample includes individuals whose blood pressure is sensitive to their salt intake and individuals whose blood pressure is not sensitive, then the superposition of these two sub-populations in a scatterplot of individuals' blood pressures against their salt intakes could give a triangular distribution. The non-correlation in the insensitives would obscure the correlation expected in the sensitives. This hypothesis justifies truncation of such data to test for correlation between blood pressure and salt intake among only the individuals in the higher range of blood pressures observed. No criterion of salt sensitivity is needed. The analysis should succeed if salt intake makes a major contribution to hypertension and would be improved if other putative causes were factored out.

performing tests of hypothesis, ..

27/04/2007 · The Effect of Truncation on Tests of Hypotheses for Normal Populations

Truncation behavior will be decreasing in the riskiness of truncation

Inducible. Next generation sequencing technologies have the tremendous potential to identify disease-causing genes in a hypothesis-free manner. In a in the American Journal of Human Genetics, mutations in the gene for the salt-inducible kinase 1 (SIK1) are found in patients with early onset epileptic encephalopathy. In addition to a previously unknown functional network related to intracellular salt in the CNS, the authors demonstrate a peculiar mutational mechanism – activating truncation mutations.

Hypothesis testing in functional linear regression …

AB - It is unclear how polyglutamine expansion is associated with the pathogenesis of Huntington disease (HD). Here, we provide evidence that polyglutamine expansion leads to the formation of large intracellular aggregates in vitro and in vivo. In vitro these huntingtin-containing aggregates disrupt normal cellular architecture and increase in frequency with polyglutamine length. Huntingtin truncated at nucleotide 1955, close to the caspase-3 cleavage site, forms perinuclear aggregates more readily than full-length huntingtin and increases the susceptibility of cells to death following apoptotic stimuli. Further truncation of huntingtin to nucleotide 436 results in both intranuclear and perinuclear aggregates. For a given protein size, increasing polyglutamine length is associated with increased cellular toxicity. Asymptomatic transgenic mice expressing full-length huntingtin with 138 polyglutamines form exclusively perinuclear aggregates in neurons. These data support the hypothesis that proteolytic cleavage of mutant huntingtin leads to the development of aggregates which compromise cell viability, and that their localization is influenced by protein length.

TY - JOUR. T1 - Hypothesis testing in functional linear regression models with Neyman's truncation and wavelet thresholding for longitudinal data
But it won’t get you the increase in nominal values we have observed, the wage truncation hypothesis has theoretical problems, ..

Oncogenic CSF3R Mutations in Chronic Neutrophilic …

If an unselected sample includes individuals whose blood pressure is sensitive to their salt intake and individuals whose blood pressure is not sensitive, then the superposition of these two sub-populations in a scatterplot of individuals' blood pressures against their salt intakes could give a triangular distribution. The non-correlation in the insensitives would obscure the correlation expected in the sensitives. This hypothesis justifies truncation of such data to test for correlation between blood pressure and salt intake among only the individuals in the higher range of blood pressures observed. No criterion of salt sensitivity is needed. The analysis should succeed if salt intake makes a major contribution to hypertension and would be improved if other putative causes were factored out.

Abstract: We propose a hypothesis of the truncation of stellar discs based on the magnetic model of the rotation curve of spiral galaxies

Bayesian Network and Simulation Software for Risk …

Abstract. We propose a hypothesis of the truncation of stellar discs based on the magnetic model of the rotation curve of spiral galaxies. Once the disc had formed and acquired its present structure, approximately, three balanced forces were acting on the initial gas: gravity and magnetic forces, inwards, and centrifugal force. When stars are formed from this gas, the magnetic force is suddenly suppressed. Gravitation alone cannot retain the newly-formed stars and at birth places beyond a certain galactocentric radius they escape to intergalactic space. This radius is the so-called “truncation radius”, which is predicted to be at about 4-5 disc radial scale lengths, in promising agreement with observations. Key words: Galaxies: structureA&A manuscript no. (will be inserted by hand later) Your thesaurus codes are: missing; you have not inserted them

(LRT) is derived for testing the null hypothesis of equal population means for truncated normal data.

This has been facilitated by several developments