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Finding Theses - The Library of Trinity College We are delighted to announce that the Library is embarking on a large digitisation project of PhD theses (selected from date range 2000-2015) and will beThesis Writing - Trinity College DublinDec 2015 Your thesis/dissertation is not the end of your study but your first piece Office guidelines; Books and websites on dissertation writing; Look forSubmitting Your Thesis - The Library of Trinity Trinity College Dublin will shortly introduce an eTheses submission system College-wide for all Schools and all research theses A system for the deposit of theResearch - Graduate Studies: Trinity College Feb 2017 The Academic Registry, on receipt of candidate s soft bound thesis submission, will notify the Director of Guidelines for PhD Examiners
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Teaching practice and taught modules. Run jointly with Colaiste Mhuire, Marino or the Froebel College of Education, Blackrock and Trinity College Dublin.
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Abstract – The applications of a range of predictive stability tools during early development will be presented. These will include in-silico tools such as bond dissociation energy predictions and Zeneth, based purely on the molecular structure and used to determine potential drug substance degradants and excipient interactions. Applications of Accelerated Stability Assessment Program (ASAP) studies across both drug substance and product will also be discussed along with packaging predictions for bottles, blisters and bulk pack configurations. A number of case studies involving different formulation types will be used to demonstrate the impact of these tools and how they can be utilised together to understand the overall stability characteristics and risks for a new drug. The impact of the predictions on the control strategy will be discussed along with how the predicted stability data was presented in regulatory submissions.
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An example of how ASAP studies have been utilised to support the development of a tablet formulation will be presented. ASAP studies were performed to support a change from a wet granulation process to roller compaction and then later in development to support the introduction of a lower strength tablet formulation. In both cases the ASAP studies focused on chemical degradation but also included dissolution studies. The presentation of the results in a regulatory submission will also be discussed.