JO - Microporous and Mesoporous Materials

Perez . utilized the click reaction to conjugate folate onto multifunctional iron oxide nanoparticles []. They synthesized poly(acrylic acid) (PAA)-coated iron oxide nanoparticles and encapsulated lipophilic fluorescence dyes (dialkylcarbocyanine fluorophores) within the hydrophobic coating layers on the nanoparticles to provide dual imaging capabilities. The nanoparticles were functionalized with alkyne groups via a reaction with propargyl amine and EDC/NHS, followed by further reaction with azide-containing folate via the click chemistry. A hydrophobic anticancer drug, Taxol, was then encapsulated to yield multifunctional theranostic nanoparticles. A thick polymeric coating layer, 40 nm thick according to DLS measurements, played a key role in incorporating hydrophobic guest molecules. The MTT and cellular uptake assessments indicated the folate-decorated nanoparticles' specificity toward target tumor cells (A549). MRI studies demonstrated the ability of those theranostic agents to behave as sensitive MRI contrast agents.

T2 - Microporous and Mesoporous Materials

JF - Microporous and Mesoporous Materials

Mesoporous materials are defined as natural or synthetic materials having a pore diameter of 2-50 nm, halfway between the pore sizes that define micro- and macroporous materials. They have a large surface area and are particularly useful for applications in catalysis, separation, and absorption.

Synthesis of Mesoporous Materials will be available on

Over the past 10 years, the concentration appears to have been on synthesis and structures of mesoporous materials. Methods of synthesis covered in the top 20 papers from this time period include block copolymer templating, oligomeric surfactant synthesis, and triblock copolymer synthesis, among others. Structures of particular interest include mesoporous materials with hybrid organic/inorganic frameworks and crystalline or semi-crystalline frameworks.

Triblock Copolymer Syntheses of Mesoporous Silica with ..

Nanotechnology is a fast‐growing area, involving the fabrication and use of nano‐sized materials and devices. Nanocomposite materials play a number of important roles in modern science and technology, including pharmaceutical science. Mesoporous materials in particular have a large number of applications. In the past decade, mesoporous silica nanoparticles (MSNs) attracted attention increasingly for their potential biomedical applications. With their tailored mesoporous structure and high surface area, MSNs have significant advantages as drug delivery systems (DDSs) compared with traditional drug nanocarriers. Inorganic mesoporous materials are being used increasingly in pharmaceutical materials research to enhance the dissolution and permeation behavior of drugs that are poorly soluble in water. The benefits of using mesoporous materials in drug delivery applications stem from their large surface area and pore volume. These properties enable the materials to accommodate large amounts of payload molecules, protect them from premature degradation and promote controlled and fast release. As carriers with various morphologies and chemical surface properties can be produced, these materials may even promote adsorption from the gastrointestinal tract to the systemic circulation. In this work, we review recent progress in the synthesis and surface functionalization of MSNs for drug delivery applications.

PEO-b-PLA diblock copolymer and F127 triblock ..

Journal of the American Chemical Society
May 2015 cover
"Multicomponent Nanomaterials with Complex Networked Architectures from Orthogonal Degradation and Binary Metal Backfilling in ABC Triblock Terpolymers"

Synthesis of Mesoporous Materials | Surfactant | Porosity

Mixed amphiphilic block copolymers of poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO–PPO–PEO) and polydimethylsiloxane-poly(ethylene oxide) (PDMS–PEO) have been successfully used as co-templates to prepare ordered mesoporous polymer–silica and carbon–silica nanocomposites by using phenolic resol polymer as a carbon precursor via the strategy of evaporation-induced self-assembly (EISA). The ordered mesoporous materials of 2-D hexagonal (p6m) mesostructures have been achieved, as confirmed by small-angle X-ray scattering (SAXS), transmission electron microscopy (TEM), and nitrogen-sorption measurements. Experiments show that using PDMS–PEO as co-template can enlarge the pore sizes and reduce the framework shrinkage of the materials without evident effect on the specific surface areas. Ordered mesoporous carbons can then be obtained with large pore sizes of 6.7 nm, pore volumes of 0.52 cm3/g, and high surface areas of 578 m2/g. The mixed micelles formed between the hydrophobic PDMS groups and the PPO chains of the F127 molecules should be responsible for the variation of the pore sizes of the resulting mesoporous materials. Through the study of characteristics of mesoporous carbon and mesoporous silica derived from mother carbon–silica nanocomposites, we think mesoporous carbon–silica nanocomposites with the silica-coating mesostructure can be formed after the pyrolysis of the PDMS–PEO diblock copolymer during surfactant removal process. Such method can be thought as the combination of surfactant removal and silica incorporation into one-step. This simple one-pot route provides a pathway for large-scale convenient synthesis of ordered mesostructured nanocomposite materials.