JO - Microporous and Mesoporous Materials
Perez . utilized the click reaction to conjugate folate onto multifunctional iron oxide nanoparticles . They synthesized poly(acrylic acid) (PAA)-coated iron oxide nanoparticles and encapsulated lipophilic fluorescence dyes (dialkylcarbocyanine fluorophores) within the hydrophobic coating layers on the nanoparticles to provide dual imaging capabilities. The nanoparticles were functionalized with alkyne groups via a reaction with propargyl amine and EDC/NHS, followed by further reaction with azide-containing folate via the click chemistry. A hydrophobic anticancer drug, Taxol, was then encapsulated to yield multifunctional theranostic nanoparticles. A thick polymeric coating layer, 40 nm thick according to DLS measurements, played a key role in incorporating hydrophobic guest molecules. The MTT and cellular uptake assessments indicated the folate-decorated nanoparticles' specificity toward target tumor cells (A549). MRI studies demonstrated the ability of those theranostic agents to behave as sensitive MRI contrast agents.
T2 - Microporous and Mesoporous Materials
JF - Microporous and Mesoporous Materials
Mesoporous materials are defined as natural or synthetic materials having a pore diameter of 2-50 nm, halfway between the pore sizes that define micro- and macroporous materials. They have a large surface area and are particularly useful for applications in catalysis, separation, and absorption.
Synthesis of Mesoporous Materials will be available on
Over the past 10 years, the concentration appears to have been on synthesis and structures of mesoporous materials. Methods of synthesis covered in the top 20 papers from this time period include block copolymer templating, oligomeric surfactant synthesis, and triblock copolymer synthesis, among others. Structures of particular interest include mesoporous materials with hybrid organic/inorganic frameworks and crystalline or semi-crystalline frameworks.