Thiazole synthesis - Organic chemistry
Synthesis of 1,3-oxazoles - Organic Chemistry Portal
Synthesis of [3-methyl-5-oxo-4-(phenyl hydrazono) 4,5-hydrazono)-4,5-dihydro-pyrazol-1-yl]-acetic acid N|-(4-substituted-thiazole-2-yl)-hydrazide XV: A mixture of [3-methyl-5-oxo-4-(phenyl hydrazono)-4,5-dihydro pyrazol-1-yl]-acetothiosemi-carbazone XIV (0.01 mole) in DMF (10 mL) and various bromoacetyl derivatives (0.01 mole) in ethanol (10 mL) was stirred at room temperature for about 2 hours. The solid separated was filtered, dried and recrystallized from ethanol-DMF mixture.
Classical oxazole synthetic methods in organic chemistry are
During 2009, six reports related to the synthesis of largazole and/or analogs were published [–]. A significant increase in potency with a pyridine substitution of the thiazole was reported. In addition, it was demonstrated that the methyl substituent of the thiazoline ring is nonessential for the dramatic potency of the natural product. In contrast, substitution of the thiazoline by thiazol, diminishes the activity .