This land is populated by "sons of Cain", men doomed to walk alone.

In protocols with bolus administration, the weight of the liver was affected in rats at the lowest dose following gavage in corn oil for 4 days (10 mg/kg body weight per day), while at higher doses (34 mg/kg body weight per day), there were histological changes in the liver (Larson et al., 1995a,b). At 15 mg/kg body weight per day, fatty cysts in the liver were observed in dogs exposed to chloroform in toothpaste base in gelatin capsules 6 days/week for 7.5 years. These changes are believed to possibly reflect mild toxicity to the hepatocytes (see main text for further discussion) (Heywood et al., 1979). At 34 mg/kg body weight per day, effects upon kidney and liver were reported in mice (Larson et al., 1994b); proliferation and lesions in the olfactory epithelium were observed at this dose in rats.

- The Chrysanthemums essays on John Steinbeck’s short story.

Poverty and unemployment were common, thus, leading to large amounts of migrant workers.

One of these novelists was John Ernst Steinbeck.

There is a story about the life of two men on those fields, working, as the author describes what happens to them through literary devices that aid the reader to understand the moral of it.

This subject is the predominant theme in John Steinbeck’s novel.

Oxidative metabolism, with CYP2E1 (an ethanol-inducible mono-oxygenase isoenzyme system present in the liver of mammals, including humans) playing a key role, is probably the only significant pathway at low exposures, and available data indicate that oxidative metabolism has a major role in toxicity. The dominant role of CYP2E1 in metabolizing chloroform to toxic metabolites has been demonstrated in studies involving treatment of animals with enzyme inducers or inhibitors, as well as studies in mice lacking CYP2E1 (Brady et al., 1989; Guengerich et al., 1991; Nakajima et al., 1995a,b; Constan et al., 1999; see also section 8.8). Immunoinhibition studies with anti-CYP2E1 monoclonal protein have shown that CYP2E1 is responsible for 81% of the metabolism assayed at a low chloroform (0.5 mmol/litre) concentration in liver microsomes from acetone-induced rats (Brady et al., 1989). Toxicity to rat and mouse hepatocytes incubated with up to 5 mmol chloroform/litre was prevented by the addition of a CYP2E1 inhibitor or by reduced oxygen tension, underscoring the importance of oxidative metabolism in toxicity (Ammann et al., 1998). Regional distribution of liver lesions in rats and mice correlates well with the hepatic distribution of CYP2E1 and glutathione (Smith et al., 1979; Ingelman-Sundberg et al., 1988; Tsutsumi et al., 1989; Johansson et al., 1990; Dicker et al., 1991; Nakajima et al., 1995a,b).


Of mice and men essays on loneliness by Kendra …

Following a 10-min inhalation exposure of mice to [14C]chloroform (dose 280 mg/kg body weight), whole-body autoradiography carried out immediately after exposure or 2 h later showed high concentrations in the fat, blood, lungs, liver, kidneys, spinal cord and nerves, meninges, and cerebellar cortex. Non-volatile radioactivity was bound in the bronchi, nasal mucosa, liver, kidneys, salivary glands, and duodenal contents. High levels of volatile or extractable radioactivity were found in testes, preputial gland, and epididymis (Bergman, 1984). Transplacental transfer has been demonstrated in rats, mice, and guinea-pigs (Nicloux, 1906; Withey & Karpinski, 1985; Danielsson et al., 1986).

Free Steinbeck Of Mice and Men Essays and Papers

CYP2B1 may also have a role in chloroform metabolism, although this is likely to be only minor at low tissue chloroform concentrations (studies reviewed in Environment Canada & Health Canada, 2001). However, at high tissue concentrations (e.g., resulting from an oral dose of 0.5 ml/kg body weight), chloroform hepatotoxicity was dramatically potentiated in Wistar rats treated with phenobarbital (a CYP2B1 inducer) but not in rats treated with -hexane (a CYP2E1 inducer), compared with uninduced controls (Nakajima et al., 1995b).

R. Melnick, National Institute of Environmental Health Sciences

- Because John Steinbeck’s novel clearly serves as social commentary, his characters have to bear out the values he wishes to illustrate or criticize.

Description and explanation of the major themes of Of Mice and Men

Steinbeck demonstrates the significance of dreams in Of Mice and Men as the essential foundation of motivation and purpose; the plans of hopeful conviction despite misery and destitution clarify the fundamental difference between ma...

SparkNotes: Of Mice and Men: Study Questions & Essay …

However, there are also some other representatives who prefer to be objective as a writer, and from my perspective, John Steinbeck should be one of them.