516Potassium Tetrachloropalladate(II) ............................

LD50 values for palladium compounds ranged, depending on compound and route tested, from 3 to >4900 mg/kg body weight, the most toxic compound being palladium(II) chloride, the least toxic, palladium(II) oxide. Oral administration caused the least toxicity. There were very similar intravenous LD50 values for palladium(II) chloride, potassium tetrachloropalladate(II) (K2PdCl4) and ammonium tetrachloropalladate(II) ((NH4)2PdCl4). Marked differences among the different routes of administration were demonstrated with palladium(II) chloride, showing in Charles-River CD1 rats LD50 values of 5 mg/kg body weight for the intravenous, 6 mg/kg body weight for the intratracheal, 70 mg/kg body weight for the intraperitoneal and 200 mg/kg body weight for the oral route. A higher oral LD50 value has been found in Sprague-Dawley rats.

537Tetrakis(acetonitrile)palladium Tetrafluoroborate .............

542Tetrakis(triisopropyl phosphite)palladium(O) ..................

547Tetrakis(triphenylphosphine)nickel(0) .........................

Palladium compounds may interact with isolated DNA . However, with one exception, mutagenicity tests of several palladium compounds with bacterial or mammalian cells (Ames test: ; SOS chromotest: ; micronucleus test: human lymphocytes) gave negative results. Also, an genotoxicity test (micronucleus test in mouse) with tetraammine palladium hydrogen carbonate gave negative results.

Tetrakis(triphenylphosphine)nickel(0) | CAS 15133-82 …

Several palladium compounds have been found to have antiviral, antibacterial and/or fungicidal properties. Standard microbial toxicity tests under environmentally relevant conditions have rarely been conducted. A 3-h EC50 of 35 mg/litre (12.25 mg palladium/litre) has been obtained for the inhibitory effect of tetraammine palladium hydrogen carbonate on the respiration of activated sewage sludge.

ALDRICH Tetrakis(triphenylphosphine)nickel(0), Ni 4 …

Some palladium compounds have been found to be potent sensitizers of the skin (palladium(II) chloride, tetraammine palladium hydrogen carbonate, palladium hydrochloride [formula not specified], palladium-albumin complexes). Palladium(II) chloride was a stronger sensitizer than nickel sulfate (NiSO4) in the guinea-pig maximization test. Guinea-pigs induced with chromate, cobalt or nickel salts did not react after challenge with palladium(II) chloride. However, if induced with palladium(II) chloride, they reacted to nickel sulfate. Somewhat divergent results have been obtained in tests studying cross-reactivity between palladium and nickel by repeated open applications to the skin of guinea-pigs. In these experiments, animals were induced with palladium(II) chloride ( = 27) or nickel sulfate ( = 30) according to the guinea-pig maximization test method and then treated once daily for 10 days according to repeated open applications testing by applying the sensitizing allergen (palladium(II) chloride or nickel sulfate) as well as the possibly cross-reactive compound (nickel sulfate or palladium(II) chloride) and the vehicle topically in guinea-pigs. In this study, it remained unclear whether reactivity to palladium(II) chloride in animals sensitized with nickel sulfate was due to cross-reactivity or to the induction of sensitivity by the repeated treatments. On the other hand, reactivity to nickel sulfate in animals sensitized with palladium(II) chloride could be attributed to cross-reactivity. Respiratory sensitization (bronchospasms) has been observed in cats after intravenous administration of several complex palladium compounds. It was accompanied by an increase in serum histamine. Significant immune responses have been obtained with palladium(II) chloride and/or chloropalladates using the popliteal and auricular lymph node assay in BALB/c mice. Preliminary data in an animal model suggest that palladium(II) compounds may be involved in induction of an autoimmune disease.

Tetrakis(triphenylphosphine)palladium(0) - WikiVisually

For example, the reactionof phosphine with formaldehyde, in the presence of hydrochloricor sulfuric acid, forms the corresponding salt of tetrakis-(hydroxymethyl)-phosphonium which is employed in the manufactureof polymers used in the flame-retardant treatment of cottonfabrics.

Tetrakis(triphenylphosphine)palladium(0) ..

: Palladium(II) chloride is prepared by the careful evaporation of a solution of hydrogen tetrachloropalladate(II) in hydrochloric acid, preferably in a rotary evaporator.