Synthesis and first application.

Our group is engaged in the development of new chemical and biological methods for the semi-synthesis of modified proteins. Protein synthesis and semi synthesis will be important in unravelling the mechanisms of action of processes involving post-translationally modified (glycosylated, phosphorylated, methylated etc..) proteins. This endeavour involves synthetic organic chemistry, molecular biology, protein expression and protein engineering. Other projects include glycosyltransferase engineering, antimicrobial peptide synthesis, and synthesis and utility of transition metal complexes. More information can be found on our research pages:

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Chemistry | SYNTHESIS - Thieme Medical Publishers

Science of Synthesis: Best methods


The three Science of Synthesis volumes on "Biocatalysis in Organic Synthesis"
present a broad contemporary overview on the state-of-the-art in enzymatic
methods for asymmetric synthesis suitable for academics and industrial
researchers working in the field of organic synthesis. The goal is to start a
new wave of enthusiasm for biocatalysis in the broader community and to give an
overview of the field. "Biocatalysis in Organic Synthesis" offers critical
reviews of organic transformations by experts, including experimental
procedures. The organization is based on the type of reaction performed under
biocatalysis.
Volume 1 begins with chapters discussing the historical development of the
field, sources of enzymes and appropriate selection of catalysts, and general
strategies employed in biocatalysis. This is followed by reviews of the
biocatalytic hydrolysis of various substrates. The volume concludes with
chapters devoted to biocatalytic isomerizations, and the synthesis of
glycosides.

General information about Science of Synthesis

The three Science of Synthesis volumes on "Biocatalysis in Organic Synthesis"
present a broad contemporary overview on the state-of-the-art in enzymatic
methods for asymmetric synthesis suitable for academics and industrial
researchers working in the field of organic synthesis. The goal is to start a
new wave of enthusiasm for biocatalysis in the broader community and to give an
overview of the field. "Biocatalysis in Organic Synthesis" offers critical
reviews of organic transformations by experts, including experimental
procedures. The organization is based on the type of reaction performed under
biocatalysis.

• Thieme Journal Award, 2010

Thieme science of synthesis | grounenlahelsisinasetitece

Ohyun Kwon received her B.S. (1991) and M.S. (1993) from Seoul National University in South Korea. In 1993, she came to the U.S. to pursue her Ph.D. (1998) from Columbia University under the guidance of S. J. Danishefsky. Her thesis work involved the synthesis of biologically significant glycolipid, asialo GM1 and Globo-H human breast tumor antigen molecule, as well as complex phomoidride terpenoids, CP-225,917 and CP-263,114. She then went to Harvard University as a Howard Hughes Postdoctoral Fellow to study chemical genetics in S. L. Schreiber's lab. There, she completed a diversity-oriented combinatorial synthesis (DOS) of a library of muticyclic compounds, as well as a library of macrocycles. Kwon joined the faculty as an assistant professor at UCLA in 2001. She has been a member of the Molecular Biology Institute (MBI) and UCLA Jonsson Comprehensive Cancer Center (JCCC) since 2005. Her research at UCLA evolves around the development of new nucleophilic phosphine catalysis reactions. The new reaction methodologies are used in the total synthesis of natural products and in the production of libraies of small organic molecules for chemical genetic applications.

Thieme Chemistry and Pharmaceutical E-Journals

In its practice, developing new organic transformations is multifaceted. As part of our endeavor to synthesize resiniferatoxin, a "vinylogous pinacol rearrangement" is proposed for the construction of hydroazulene system from trans -decalin framework. This new reaction is of critical use for the synthesis of resiniferatoxin.

Science of Synthesis by Thieme Publishing Group - issuu

Our research interest lies in the area of development of new methodologies for organic transformations, target oriented synthesis of biologically important natural compounds, and diversity oriented synthesis of natural product-like molecules. Molecules thus built will be employed in the investigation of biologically significant processes. Each project described below encompasses more than one area of these research interests.

At Thieme, we like different aspects of chemical synthesis

Emergence of vancomycin-resistant Enterococcus (VRE) in conjunction with methhicillin-resistant S. aureus (MRSA) has become a tremendous threat to human health since vancomycin has been the last resort for treating infections caused by MRSA. Isolation of guanacastepene A and its antibiotic activity against MRSA and VRE has attracted many interests in the synthetic community. We are also involved in the concise 14-step synthesis of guanacastepene A. Unfortunately, guanacastepene A demonstrates hemolytic activity as well as its activity against multi drug-resistant strains of pathogenic bacteria. Our plan is to apply the scheme developed in its total synthesis to the solid-phase split-pool synthesis of guanacastepene analogs. Combined with comparative assays against red blood cells and pathogenic bacteria, a library of guanacastepene A-like compounds presents a possibility of discovering a new multi drug-resistant antibiotic.