Synthesis of novel thin film nanocomposite (TFN) …

AB - The cytotoxic activity of immunotoxins constructed with human diferric transferrin (Tfn) as the carrier ligand and an abrin variant Pseudomonas exotoxin A (PE) and the diphtheria toxin mutant cross-reacting material (CRM) 107 as the toxin moieties were studied in vitro. Three malignant human cell lines, the glioblastomas multiforme SNB19 and SF295 and the LOX melanoma, and a nonhuman control murine melanoma cell line B16 were assessed. The presence of transferrin receptors on the cell lines was confirmed by direct 125I- Tfn binding assays. The 50% protein synthesis inhibitory concentration (IC50) values for all cell lines demonstrated that Tfn-abrin variant and Tfn-PE had comparable potency and were both more effective than Tfn-CRM 107. Monensin, a carboxylic ionophore, potentiated the effect of Tfn-abrin variant against glioma cells approximately 35-fold with IC50 values of 4.0 x 10- 13 M and 4.7 x 10-12 M for SNB19 and SF295, respectively. Cytotoxic activity of Tfn-abrin variant (with or without monensin) and Tfn-PE was correlated with the degree of Tfn receptor expression measured on the cell lines. The exquisite in vitro cytotoxicity of Tfn-abrin variant and Tfn-PE immunotoxins against glioma and melanoma cells warrants further in vivo evaluation and future consideration of these agents for potential clinical application against glioblastoma multiforme and leptomeningeal neoplasia.

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Synthesis of TFN-Loaded Stabilized Nanovesicles.

A recent progress in thin film composite membrane: A review

N,N-dimethylamino-functionalized basic ionic liquid catalyzed one-pot multicomponent reaction for the synthesis of 4H-benzo[b]pyran derivatives under solvent-free condition.

DOI : 10.1021/cr200190s - American Chemical Society

AB - In the present study, the self-synthesized thin film nanocomposite (TFN) membrane incorporated with hydrophilic functionalized titanate nanotubes (TNTs) has been fabricated and tested for forward osmosis (FO) desalination. The ATR-FTIR results showed that NH2-TNTS were successfully modified by AATPS and while TEM and XRD revealed the tubular morphology and crystal structure of NH2-TNTs nanotubes, respectively. The presence of the chemical bondings between NH2-TNTs and polyamide (PA) selective top layer of TFN is corroborated with the FTIR results. The existence of NH2-TNTs in PA top layer was further confirmed by XPS analysis on the control and TFN membranes. The effect of NH2-TNTs on the PA layer was investigated and discussed in terms of surface morphology and separation performance. The morphology of the PA layer was investigated through FESEM and AFM micrographs and the outgrowth of the "leaf-like" structure was observed following the increase in NH2-TNTs content. Compared to the thin film composite (TFC) control membrane, the TFN membrane embedded with 0.05wt% NH2-TNTs (designated as TFN0.05) exhibited two times improvement in water flux without sacrificing salt rejection.

Ionic liquid promoted efficient and rapid one-pot synthesis of pyran annulated heterocyclic systems.
Synthesis and characterization of novel thin film nanocomposite (TFN) membranes embedded with halloysite nanotubes (HNTs) for water desalination

1426 BCE or : the Twelve Hours of the Night and the Midnight Mystery

N2 - In the present study, the self-synthesized thin film nanocomposite (TFN) membrane incorporated with hydrophilic functionalized titanate nanotubes (TNTs) has been fabricated and tested for forward osmosis (FO) desalination. The ATR-FTIR results showed that NH2-TNTS were successfully modified by AATPS and while TEM and XRD revealed the tubular morphology and crystal structure of NH2-TNTs nanotubes, respectively. The presence of the chemical bondings between NH2-TNTs and polyamide (PA) selective top layer of TFN is corroborated with the FTIR results. The existence of NH2-TNTs in PA top layer was further confirmed by XPS analysis on the control and TFN membranes. The effect of NH2-TNTs on the PA layer was investigated and discussed in terms of surface morphology and separation performance. The morphology of the PA layer was investigated through FESEM and AFM micrographs and the outgrowth of the "leaf-like" structure was observed following the increase in NH2-TNTs content. Compared to the thin film composite (TFC) control membrane, the TFN membrane embedded with 0.05wt% NH2-TNTs (designated as TFN0.05) exhibited two times improvement in water flux without sacrificing salt rejection.

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Abklex: Lexikon von Abkuerzungen aus Informatik und Telekommunikation

The ability of engineering aminoacyl-tRNA synthetases is critical in successful incorporation of analogues into proteins. We have developed a high-throughput method of screening methionyl-tRNA synthetase (MetRS) libraries for global incorporation of noncanonical amino acids. A variant of GFP was engineered to permit incorporation of analogues into its Met sites with minimal loss of fluorescence. Using this variant as a translational reporter, we screened a library of E coli MetRS variants for activity toward 6,6,6-trifluoronorleucine, and identified a MetRS mutant that enabled high-yield expression of recombinant proteins with quantitative replacement of Met with Tfn.

Synthesis, modification and optimization of titanate nanotubes-polyamide thin film nanocomposite (TFN) membrane for forward osmosis (FO) application

Synthesis, modification and optimization of ..

T1 - Synthesis, modification and optimization of titanate nanotubes-polyamide thin film nanocomposite (TFN) membrane for forward osmosis (FO) application