Synthesis of N-(m, p)-Vinylbenzyliden-Procaine (Im)

In the same study, 30 male and 27 female rats were dosed by oral gavage with [14C]sodium 2-(4-methoxyphenoxy) propanoate at 50 mg/kg bw (5 µCi/ml) 18 days after mating. Groups of three male and three female animals were killed 0.5, 1, 3, 5, 7, 12, 24, 48, 72 and 96 h after dosing, and blood was sampled and tissues and organs were removed. Sodium 2-(4-methoxyphenoxy) propanoate was rapidly absorbed and eliminated by both male and female rats. Only 12% (range, 6.3–23%) and 2.6% remained in the stomach of males and females after 0.5 h, indicating that absorption was slightly faster in females than in males. The total radioactivity was greatest in the liver (2.5% for males and 3.1% for females) and kidney (2.1% for males and 2.5% for females), the concentration of radioactivity being 3.5 times greater in the kidney than in the liver. Loss of radioactivity from tissues and organs was rapid, elimination being essentially complete with 24 h (Brown et al., 1986).

Synthesis of Two Local Anesthetics From Toluene - Scribd

Synthesis of Two Local Anesthetics From Toluene

Synthesis of Two Local Anesthetics from Toluene: ..

It is rapidly excreted by the kidneys.

INDICATIONS:
Benzyl penicillin is highly active against gram-positive cocci and is similar to that of penicillin V in aerobic gram-positive micro-organisms.

Synthesis Reference US812554 ..

In general one serving of coffee ranges from about 40 milligrams for a single shot (30 milliliters) of -variety espresso to about 100 milligrams for strong drip coffee.

Examples of HABs Obtained by Programmed Synthesis image EurekAlert! Science News

lacking the terminal diethylamino group of procaine, ..

Numerous studies have been conducted to evaluate the effect of phenethyl alcohol on excision repair of DNA damage induced by ultraviolet radiation (UV) in non-standard strains. When solutions (0.2 and 0.4%) of phenethyl alcohol were incubated with UV-damaged strains H/r 30 and B (wild-type), excision repair of membrane-associated DNA was inhibited, as measured by a decrease in liquid holding recovery and a decrease in the removal of thymine dimers. The authors hypothesized that excision repair may require that DNA is bound to the cell membrane, and the test article may have inhibited that binding (Tachibana & Yonei, 1985). Similar results were obtained in an earlier study, in which it was shown that 0.05–0.5% solutions of phenethyl alcohol caused detachment of DNA from the DNA–membrane complex in B cells. The effect was concentration-dependent. Similar results were obtained with NG30 (rec A mutant) (Tachibana et al., 1982). In a related study, phenethyl alcohol inhibited the removal of thymine dimers from DNA in what was considered to be the incision step of excision repair in (Tomiyama et al., 1986). Phenethyl alcohol thus inhibited excision repair of UV-damaged DNA in (Yonei, 1980; Todo & Yonei, 1983; Tachibana & Yonei, 1985).

23/09/2006 · Synthesis of Methylsilyl Derivates of Procaine and Their Diffusion Rates from an Ointment Base

Preparing procaine and procaine monohydrochloride …

Phenoxyacetic acid was administered by gavage to mice on one of days 8–15 of gestation at a dose of 800–900 mg/kg bw or on three consecutive days (7–9, 10–12 or 13–15) at a dose of 250–300 mg/kg bw per day. Treated females were killed on day 18 of gestation, and their uteri were examined to determine the numbes of live, dead and resorbed fetuses. Live fetuses were examined for gross external malformations and weighed. Fetuses from each litter were further examined for visceral abnormalities and skeletal malformations. The authors stated that phenoxyacetic acid was not strongly teratogenic or fetotoxic (Hood et al., 1979).

Benzocaine was used in synthesis of leteprinim

In the second part of this study, phenoxyethyl alcohol was administered after weaning to the last F1 litter at the same dose provided to their F0 parents. A dose-related decrease in body weight was seen in the F1 generation at the two higher doses, from birth to post natal day 74. Increased mortality was reported at the two higher doses from weaning until postnatal day 74, with marked effects at the highest dose, only 6/56 pups surviving until mating. Consequently, this group was terminated. After mating of the F1 generation, no treatment-related effects were seen on F2 litter size or sex ratio. The weights of live F2 pups at the intermediate dose were decreased by 7%. Necropsy of these mice and of the controls revealed decreased body weight (13% less), decreased absolute testis weight (16% less), decreased relative seminal vesicle weight (14% less) in the male mice and decreased body weight (7%) in the female mice in comparison with the controls. No effects were reported on epididymal sperm concentration, motility or morphology. The decrease in body weight reported for live male F1 pups born to the pairs given the low dose (F0) was barely statistically significant, and its biological relevance is questionable as it was observed in male pups only. The NOEL for reproductive effects was 0.25%, corresponding to 380 mg/kg bw per day (National Toxicology Program, 1984).

Entries Tagged as 'Procaine (Novocaine)' ..

Groups of 10–16 male and female Charles River CD rats were given diets adjusted during the study to provide constant concentrations of 1.5 mg/kg bw per day for males and 1.8 mg/kg bw per day for females of phenethyl senecioate, 15 mg/kg bw per day for males and 16 mg/kg bw per day for females of ethyl (-tolyloxy) acetate or 17 mg/kg bw per day for males and 19 mg/kg bw per day for females of isopropylphenylacetaldehyde. The animals were housed in pairs of the same sex and given access to water and food. The doses were chosen by methods described by Oser & Hall (1977). Clinical observations were recorded daily, and food consumption and body weights were determined weekly. During weeks 7 and 13, haematological and clinical chemical (blood urea) parameters were measured. After 90 days, all the animals were killed and subjected to detailed necropsy, and the liver and kidneys were weighed. A wide range of tissues and organs from each animal was preserved, and major organs and tissues were examined histologically.