T1 - Solid-Phase Synthesis of 5-Isoxazol-4-yl-[1,2,4]oxadiazoles

Keeping this in view, it was thought worthwhile to design the synthesis of the title compounds. The present communication reports the synthesis of unknown 5-(Hydroxyphenyl)methyl-2-alkyl/arylamino-1,3,4-oxadiazoles (4a-i) and 5-(Hydroxyphenyl) methyl-2-mercpto-1,3,4-oxadiazoles (4j) and evaluation of their anti-inflammatory activity.

Synthesis of 1,3,4-oxadiazoles - Organic Chemistry Portal

T1 - Synthesis and biological activity of 2-(4,5-dihydroisoxazol-5-yl)-1,3,4-oxadiazoles

Synthesis of 1,2,4-oxadiazoles - Organic Chemistry Portal

A series of α-amino acid-derived 1,2,4-oxadiazoles have been synthesized via an easy, inexpensive and one-pot protocol. The heterocycles were obtained in good yields and in relatively short reaction times.

Synthesis of 2-Amino-1,3,4-oxadiazoles and 2-Amino …

Physical data of 5-furyl-2-aryl - 1, 3, 4 - oxadiazoles are given in Table 1. All the synthesized compounds have shown antioxidant activity to certain extent. Results of the screening studies are given in Table 2 & 3.

T1 - Hypervalent Iodine-Catalyzed Synthesis of 1,2,4-Oxadiazoles from Aldoximes and Nitriles

Synthesis of N, N΄3, 4-Dialkylamino-1, 2, 5-Oxadiazoles

Among a wide variety of heterocycles that have explored for developing pharmaceutically important molecules, 1,3,4 oxadiazoles constitute an important group due to their wide variety of biological activity and find wide usage as dyes, photosensitive electrical materials, polymer precursors, stabilizers, their synthesis and transformations have received great attention for a long time. Oxadiazole is a five membered heterocycle having two carbons, two nitrogen, one oxygen and two double bonds. The percentage of C, H, N present in 1, 3, 4-Oxadiazole is

Synthesis of 1,3,4-Oxadiazoles and 1,3-Thiazolidinones ..

INTRODUCTION: From the past few decades the research on furoic acid derivative revealed that the derivative had wide range of therapeutic application 18 and 1, 3, 4- oxadiazoles are biologically active 15, 16, synthetically useful and important heterocyclic compounds.

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A series of five membered heterocyclics was synthesized by the reaction between refluxing 2 - furoic acid with ethanol and conc. H2SO4. The obtained ester (2) with hydrazine hydrate and ethanol was refluxed to give hydrazides (3). Reaction of hydrazides (3) with different aromatic acids using phosphorousoxy trichloride (POCl3) lead to the formation of 2-Aryl -5-furyl -1, 3, 4-oxadiazoles [DM (1-6)], and was tested for their antioxidant activity. The synthesized compounds were characterized by IR, 1HNMR and Mass Spectroscopy. All the compounds were screened for in vitro antioxidant activity by DPPH method and nitric oxide scavenging assay. Among the synthesized compounds DM-1, DM-2 and DM-4 were found to be promising compounds of the series substituted with electron donating groups like methoxy and hydroxyl showed higher antioxidant activity.

Synthesis of 4‐Aminopyrimidines from 1,2,4‐Oxadiazoles…

A series of 5-(pyridin-4-yl)--substituted-1,3,4-oxadiazol-2-amines (3ad), 5-(pyridin-4-yl)--substituted-1,3,4-thiadiazol-2-amines (4ad) and 5-(pyridin-4-yl)-4-substituted-1,2,4-triazole-3-thiones (5ad) were obtained by the cyclization of hydrazinecarbothioamide derivatives 2ad derived from isonicotinic acid hydrazide. Aminoalkylation of compounds 5ad with formaldehyde and various secondary amines furnished the Mannich bases 6ap. The structures of the newly synthesized compounds were confirmed on the basis of their spectral data and elemental analyses. All the compounds were screened for their anticancer activity against six human cancer cell lines and normal fibroblast cells. Sixteen of the tested compounds exhibited significant cytotoxicity against most cell lines. Among these derivatives, the Mannich bases 6j, 6m and 6p were found to exhibit the most potent activity. The Mannich base 6m showed more potent cytotoxic activity against gastric cancer NUGC (IC50=0.021 µM) than the standard CHS 828 (IC50=0.025 µM). Normal fibroblast cells WI38 were affected to a much lesser extent (IC50>10 µM).