Increased Synthesis of Leukotrienes in the Mouse …
Gender variation in the synthesis of leukotrienes.
Leukotrienes are eicosanoids which means they are a collection of oxygen derivatives of some 20 different essential fatty acids. The other eicosanoids are prostaglandins, prostacyclins and thromboxanes. Leukotrienes are produced along with the release of histamine. Leuko trienes are one class of eicosanoids lipid mediators which means they are signalling molecuels which occur by the of essential fatty acids at the site of inflammation or where is required. These are derived from omega-3 fatty acids or the omega-6 fatty acids. There is no storage for leukotrienes as they have to be synthesized wherever they are required.
Total Synthesis of Leukotrienes from Butadiene, …
White Blood cells or WBC’s are known for their immunity building role in our body. Leukotrienes are one of the defense weapons of white blood cells which are lipids and play a pivotal role in immunity increasing function. They can also be expressed as the hormones which cause symptoms in asthma and hay (allergic rhinitis). They are responsible for activating many different types of white cells so as to fight the foreign material/organism invasion in our body. Biologists have found out that malfunctioning of Leukotrienes can result in aggravation of asthma and other diseases too.
American Journal of Respiratory and Critical Care Medicine
Although cells of the myeloid lineage are well-recognized sources of leukotriene production, an alternative synthetic pathway for leukotrienes involves transcellular metabolism., In this two-cell process of leukotriene synthesis, the donor cell (believed to be a bone marrow-derived cell, such as the neutrophil or the macrophage) generates LTA4, which then passes transcellularly to the recipient cell, where it is further metabolized to downstream leukotrienes, depending on the enzymatic repertoire of the recipient cell. In a model of neuronal ischemia in the brain, glial cells demonstrated the enzymatic capability to produce leukotrienes by transcellular biosynthesis. It is hypothesized that the local recipient cell generation of leukotrienes may cause focal areas of prolonged inflammation and tissue injury.,,