Making insect repellents safe (letter).

In the preparation of the insect repellent DEET, lab procedures prepare the intermediate -toluoyl chloride by heating -toluic acid with thionyl chloride for times ranging from 15 to 45 minutes. The acid chloride is then worked up under Schotten-Baumann conditions to yield DEET. In our students' hands, these procedures gave a darkly colored product which was contaminated with an anhydride by-product. We have shown that the -toluoyl chloride can be prepared at room temperature in 8 minutes and that the eventual DEET product is obtained in excellent yield without the dark coloration or anhydride by-product.

Toxicity of diethyltoluamide-containing insect repellents.

It is recognized as the most effective repellent against Aedes aegypti and Aedes taeniorhynchus.

Pharmacokinetics of insect repellent N,N-diethyltoluamide.

In recent years a variety of formulations havebeen developed to minimize DEETís unpleasant characteristics when used as askin repellent, and also to lengthen the duration of its effectiveness.

The safety of Diethyltoluamide insect repellents (letter).

Pesticides include many more products than just insect repellants, though. Common pesticides found in the home include weed killers, ant traps, flea treatments, rat poison and disinfectants. Every product classified as a pesticide is required to give standard information on the label. Click on the graphic to the right for a guide to reading a pesticide label.

Advice should be given against extended, excessive use of the repellent.

Novel Insect-Repellent Coumarin Derivatives, Syntheses, and ..

Summer is here and many of us in northern New England will be spending more time outside. It’s a busy time for everyone, including the Northern New England Poison Center. During the warmer months, the poison center manages many calls about pesticides, such as insect repellants, often referred to as bug spray.

"Mosquitoes smell and avoid the insect repellent DEET"

2-Undecanone is used in the perfumery and flavoring industries, but because of its strong odor it is primarily used as an insect repellent or animal repellent.

Insect Shield is an insect repellent technology that ..

(Mechanicalrepellents, such as high frequency emitters, marketed for insects or otherpests are generally unproven and ineffective)Formulations with Combinations of Pesticides

Toxic encepholopathy apparently related to the use of an insect repellent.

d 7 Propose a synthesis of the insect repellent DEET …

Insect repellants with DEET can be very effective at preventing bites from mosquitos, ticks and other pests. This can this help you avoid pain and itchiness from bites, and also help prevent diseases such as Lyme. Depending on the amount of DEET in the product, an insect repellent will keep ticks away for two to ten hours, and mosquitoes for two to twelve hours.

Review of the distribution and toxicity of the inset repellent N,N-diethyl-m-toluamide (DEET).

The Chemistry of Insect Repellents

Take special care with children. Products with a concentration of 30% DEET or less have been shown to be safe for children older than two months. An adult should always apply insect repellants to children. Avoid using the product on children’s hands.

Toxic encephalopathy in a child after brief exposure to insect repellents.

Preparation of the Insect Repellent N - Preparation of …

Accumulation within the body has not been reported (Heick et al, 1980), and experimentally there have been no cumulative effects of subtoxic doses of DEET; but case reports toxicity in man suggest that accumulation of the repellent may occur, with deleterious effects (Zadicoff, 1979).