Synthesis of imides - Organic chemistry

The atom‐economical and operatively simple syntheses of succinimides, phthalimides, and glutarimides, which are important building blocks in natural products and drugs, was also demonstrated.

19/09/2005 · Synthesis of Imides, ..

Photovoltaic Properties of New Cyanine-Naphthalimide Dyads Synthesized by 'Click' Chemistry.

An expeditious synthesis of cyclic imides - ScienceDirect

N2 - Naphthalimmide (NI) and 1,4,5,8-naphthalentetracarboxylic diimide (NDI) derivatives were synthesized and evaluated for their antiproliferative activity. NDI derivatives 1-9 were more cytotoxic than the corresponding NI derivatives 10-18. The molecular mechanisms of 1 and 2 were investigated in comparison to mitonafide. They interacted with DNA, were not topoisomerase IIR poisons, triggered caspase activation, caused p53 protein accumulation, and down-regulated AKT survival. Furthermore, 1 and 2 caused a decrease of ERK1/2 and, unlike mitonafide, inhibited ERKs phosphorylation. ∞ Dedicated to Professor Fulvio Gualtieri on the occasion of his retirement.

Synthesis of α-Keto-Imides via Oxidation of Ynamides - …

AB - Naphthalimmide (NI) and 1,4,5,8-naphthalentetracarboxylic diimide (NDI) derivatives were synthesized and evaluated for their antiproliferative activity. NDI derivatives 1-9 were more cytotoxic than the corresponding NI derivatives 10-18. The molecular mechanisms of 1 and 2 were investigated in comparison to mitonafide. They interacted with DNA, were not topoisomerase IIR poisons, triggered caspase activation, caused p53 protein accumulation, and down-regulated AKT survival. Furthermore, 1 and 2 caused a decrease of ERK1/2 and, unlike mitonafide, inhibited ERKs phosphorylation. ∞ Dedicated to Professor Fulvio Gualtieri on the occasion of his retirement.

Design, Synthesis, and Preliminary Biological Evaluation of a Novel Triazole Analogue of Ceramide.

Synthesis of antitumor dendritic imides - DeepDyve

Polyamideimides are either prepared from an aromatic diamine and aromatic acid chloride anhydride (acid chloride route) or from an aromatic diisocyanate and anhydride (diisocyante route). A common reaction is the addition of a trimellitic acid anhydride (TMAC) to a methylene diamine usually at ambient or elevated temperatures (20 - 60°C) in a dipolar aprotic solvent, such as dimethyl sulfoxide (DMSO), N-methyl-2-pyrrolidone (NMP) or N,N-dimethylacetamide (DMAc). The second step is the conversion of the amic acid groups to the cyclic imides at elevated temperatures (post-cure).

Being highly polar, imides exhibit good solubility in polar media

Polyamideimides (PAIs) are high performance amorphous engineering thermoplastics of yellow to brown color. They have outstanding thermal, mechanical, and chemical properties and are often the best choice for demanding applications where very high mechanical strength, stiffness and low friction in combination with high temperature, corrosion, and wear resistance is required.1 Compared to typical polyimides, PAIs have a lower continuous service temperature but a higher fracture toughness. For example, some grades maintain their strength and stiffness up to 500°F (260°C) whereas some can be operated up to 700°F (370°C). Like PIs, PAIs resist most chemicals and can be operated in harsh thermal and chemical environments even under severe stress with little to no creep, wear, and chemical degradation. They are virtually unaffected by aliphatic and aromatic hydrocarbons as well as chlorinated and fluorinated solvents. Some grades also resist concentrated acids (30%) including hydrochloric, phosphoric, and sulfuric acid but are attacked by hydrofluoric acid and strong bases such as sodium hydroxide.2 In many cases, they can replace metals and other high performance materials in structural applications.3

R., Regioselective synthesis of a new [1,2,3]-triazoles directly from imidates.

Synthesis and reactivity of asymmetric bis(sulfonyl) imides

The atom‐economical and operatively simple syntheses of succinimides, phthalimides, and glutarimides, which are important building blocks in natural products and drugs, was also demonstrated.">

A., Synthesis of complex alkoxyamines using a polymer-supported -hydroxyphthalimide.

The Synthesis of Unsubstituted Cyclic Imides Using ..

Naphthalimmide (NI) and 1,4,5,8-naphthalentetracarboxylic diimide (NDI) derivatives were synthesized and evaluated for their antiproliferative activity. NDI derivatives 1-9 were more cytotoxic than the corresponding NI derivatives 10-18. The molecular mechanisms of 1 and 2 were investigated in comparison to mitonafide. They interacted with DNA, were not topoisomerase IIR poisons, triggered caspase activation, caused p53 protein accumulation, and down-regulated AKT survival. Furthermore, 1 and 2 caused a decrease of ERK1/2 and, unlike mitonafide, inhibited ERKs phosphorylation. ∞ Dedicated to Professor Fulvio Gualtieri on the occasion of his retirement.

Because of their high price, polyamideimides are usually only used when outstanding properties are required.

Find out information about Phthalimide

However, polyamideimides have also some limitations and shortcomings. For example, they are rather expensive and often require a post-cure to achieve their full potential especially maximum wear and chemical resistance. They also cannot be used above their glass transition temperature unless cross-linked.