Synthesis of hyperbranched polymers via thiol-yne click chemistry.

Combination of Ring-Opening Polymerization and "Click" Chemistry for the Synthesis of an Amphiphilic Tadpole-Shaped Poly(ε-Caprolactone) Grafted by PEO.

“Synthesis of Hyperbranched Polymers via Thiol-yne Chemistry.” .

“Synthesis of Hyperbranched Polymers via Thiol-yne Chemistry.” In , 215–215.

Recent Advances in the Synthesis of Well-Defined Glycopolymers.

120. Chan P, Kurisawa M, Chung JE, Yang YY. Synthesis and characterization of chitosan-g-poly(ethylene glycol)-folate as a non-viral carrier for tumor-targeted gene delivery. 2007;3(28):540-549

Modular Synthesis of ABC Type Block Copolymers by "Click" Chemistry.

122. Zhou HF, Yu WT, Guo X, Liu XD, Li N, Zhang Y, Ma XJ. Synthesis and characterization of amphiphilic glycidol-chitosan-deoxycholic acid nanoparticles as a drug carrier for doxorubicin. 2010;12(11):3480-3486

Definitions - Dendrimers and Hyperbranched Polymers

Functional Hyperbranched Polymers for Tissue Engineering, from Reversible Deactivation Radical Polymerizations Approaches
(Yixiao Dong, Stanford University School of Medicine, Stanford, CA, USA, and others)


Hyperbranched polymers have a very large number of ..

Clear, thorough discussions include: How irregular branching affects polymer properties and their potential applications Important theoretical basics, plus a useful summary of characterization techniques How hyperbranched polymers compare with dendrimers as well as linear polymers Future trends in the synthesis and application of hyperbranched polymers Geared to novices and experts alike, Hyperbranched Polymers is a must-have resource for anyone working in polymer architectures, polymer engineering, and functional materials.

Synthesis of hyperbranched polymers via a ..

Synthesis of Functionalized NMP Initiators for Click Chemistry: a Versatile Method for the Preparation of Functionalized Polymers and Block Copolymers.

Download Hyperbranched Polymers: Synthesis, …

No matter HMW PEIs or LMW PEIs, intracellular release of DNA from the complexes is of the utmost importance for the transfection efficiency. In order to trigger intracellular release of therapeutic genes from cross-linked PEI, there are two promising methods, hydrolytic degradation and disulfide reduction. Disulfide cross-linked polymers were synthesized to stimulate the DNA release in the cytoplasm by intracellular reducing environment [].

17/05/2010 · The hyperbranched polymers ..

Hyperbranched polymers (HBPs), comprising of dendritic units, linear units and terminal units, are highly branched macromolecules with three-dimensional dendritic globular architecture. Compared with linear polymers, HBPs have shown the characteristics of a large population of terminal functional groups, low or no chain entanglement, small hydrodynamic diameter, low solution or melt viscosity and good solubility. Due to these characteristics, HBPs have attracted global interest from science to industry. In this paper, we review some progress in the synthesis, self-assembly and application of HBPs. The paper includes three parts. In the first part, a short history on the development of HBPs focusing on the introduction of "couple-monomer methodology (CMM)" to prepare HBPs was discussed. A typical example of CMM named as "AA'+B'B2" method was described. In addition, the synthesis of a hyperbranched oxetanemethanol through ring-opening polymerization was also presented. In the second part, the self-assembly of amphiphilic HBPs was summarized according to the morphology of the self-assemblies from the spherical micelles, the vesicles, the sheets or films, the fibers or tubes, to complex supramolecular structures. The mechanism for the self-assembly of the micelles from HBPs was discussed in details. HBPs form unimolecular micelles (UMs) around 10 nm below the critical micellar concentration (CMC). Above the CMC, there are two possibilities for the formation of micelles:one is that HBPs undergo microphase separation and then form micelles with the diameter of the length of two HBPs (around 20 nm or larger), which is named as "microphase-separated small micelles" (ms-SMs) and similar to the star micelles of linear block copolymers in structure; the other is that HBPs form multimolecular micelles (>50 nm) through a mechanism of "multimicelle aggregate" (MMA). The MMA mechanism can also be divided into two mechanisms of "unimolecular micelle aggregate" (UMA) and "small micelle aggregate" (SMA). The MAA mechanism is general and can also be used to explain the large multimolecular micelles self-assembled from other polymers or even small molecules. In the third part of this review, we introduced the applications of HBP self-assemblies in drug delivery, cytomimetic chemistry and monodisperse nanoparticle preparation. The HBP vesicles (named as branched-polymersomes) have displayed good properties like the simple preparation, good membrane fluidity and stability, and the facilely tuned and micrometer-scaled size, which make them the ideal model systems to mimic cell behaviors like fusion, fission, aggregation and so on. All these cytomimetic behaviors can be observed in real time under an optical microscope since the branched-polymersomes have a cell-like size.