Synthesis of epoxides using :

Our programs are tied by the common theme of organic synthesis. We are interested in the development of new reactions and reagents for natural product total synthesis, and we have contributed a variety of new reactions to the chemist's arsenal, including free radical-mediated aryl and vinyl amination, the Brønsted acid-catalyzed aza-Darzens reaction, and a new acid catalyzed olefin aminoacyloxylation reaction. We also apply these reactions to the targets that inspired them. For example, our synthesis of mitomycin C uses the acid-catalyzed aza-Darzens reaction, in addition to a regioselective enamine-quinone coupling. And in our approach to (+)-zwittermicin A, we deploy a variation of our Brønsted acid catalyzed azide-olefin addition. As a result, we are able to synthesize highly functionalized, stereochemically dense advanced intermediates with considerable brevity. We reported the first total synthesis of (+)-serratezomine A using the free radical-mediated vinyl amination reaction, which provided this challenging target in a mere 15 steps (longest linear sequence).

Fokin, Efficient Synthesis of 2-Substituted-1,2,3-triazoles,

T1 - Synthesis of stilbene carboxylic acids as scaffolds for calcium sensors

Fokin, Copper(I)-Catalyzed Synthesis of Azoles.

Sharpless, Asymmetric Dihydroxylation of Acrolein Acetals: Synthesis of Stable Equivalents of Enantiopure Glyceraldehyde and Glycidaldehyde, , 33, 2095 (1992).

Sharpless, Synthesis of Aryl Serines, U.S.

Sharpless, Syntheses and Crystal Structures of the Cinchona Alkaloid Derivatives used as Ligands in the Osmium-Catalyzed Asymmetric Dihydroxylation of Olefins,


Molecular Weight: 163.057 g/mol

“Organocatalytic, Diastereo- and Enantioselective Synthesis of Nonsymmetric cis-Stilbene Diamines: A Platform for the Preparation of Single Enantiomer cis-Imidazolines for Protein-Protein Inhibition” Vara, B. A.; Mayasundari, A.; Tellis, J. C.; Danneman, M. W.; Arredondo, V.; Davis, T. A.; Min, J.; Finch, K.; Guy, R. K.; Johnston, J. N. J. Org. Chem. 2014, 79, 6913–6938. PMC4120989

Synthesis of trans-Stilbene oxide - Chempedia - LookChem

“Brønsted Acid-Catalyzed Phosphoramidic Acid Additions to Alkenes: Diastereo- and Enantioselective Halogenative Cyclizations for the Synthesis of C- and P-Chiral Phosphoramidates” Toda, Y.; Pink, M.; Johnston, J. N. J. Am. Chem. Soc. 2014, 136, 14734–14737. PMC4210055

Synthesis Of Stilbene By Wittig Reaction Free Essays

Hawker, Role of Architecture and Molecular Weight in the Formation of Tailor-made Ultrathin Multilayers Using Dendritic Macromolecules and Click Chemistry,

Synthesis of (–)-g-Amino-b-(R)-Hydroxybutyric Acid (GABOB).

Sharpless, Syntheses of Diols by Catalytic Dihydroxylation Reactions, "Applied Homogeneous Catalysis by Organometallic Complexes", Boy Cornils and Wolfgang A.

Young, The Utility of Selenium Reagents in Organic Synthesis, , Vol.

Sharpless, A Click Chemistry Approach to Tetrazoles by Huisgen 1,3-Dipolar Cycloaddition: Synthesis of 5-Sulfonyl Tetrazoles from Azides and Sulfonyl Cyanides,

Sharpless, Synthesis of Resin Acid Intermediates.

Fokin, Rapid Discovery and Structure-Activity Profiling of Novel Inhibitors of HIV-1 Protease Enabled by the Copper(I)-Catalyzed Synthesis of 1,2,3-Triazoles and Their Further Functionalization,