Dangers of diglyme | The Safety Zone

Data on the degree of recycling of diglyme from its application as a solvent or as an inert reaction medium in industrial processes are not available.

Less polar solvents failed (toluene, diglyme).

Syntheses and crystal structures of vanadium and iron chloride complexes with diglyme.
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Search results for diglyme at Sigma-Aldrich ..

Because of its dipolar aprotic properties and its chemical stability (see sections 2 and 5.2), diglyme is used mainly as a solvent, as an inert reaction medium in chemical synthesis, and as a separating agent in distillations. These uses include industrial applications, such as polymerization reactions (e.g., of isoprene, styrene), the manufacture of perfluorinated organic compounds (BUA, 1993a), reactions in boron chemistry (Brotherton et al., 1999; Rittmeyer & Wietelmann, 1999), and its application as a solvent for, for example, textile dyes, lacquers, and cosmetics (BUA, 1993a; Baumann & Muth, 1997).

Synthesis of Bu4NB11H14by the Reaction of ..

Diglyme is manufactured in a closed system by the catalytic conversion of dimethyl ether and ethylene oxide under elevated pressure (1000–1500 kPa) and temperatures (50–60 °C) with a maximum yield of 60%. The by-products tri- and tetraethylene glycol dimethyl ether and small amounts of a high-molecular-mass ethylene glycol dimethyl ether are separated by fractional distillation (Hoechst, 1991). This process is based on the classic Williamson ether synthesis (Rebsdat & Mayer, 1999).

There is a potential for inhalation or dermal contact in the chemical and allied product industries where diglyme is used as a solvent.
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(2005), Synthesis of Lanthanide Bromide Complexes from Oxides

According to the X-ray analyses, the compounds 1 and 2 crystallize as solvent separated ion pairs, the complexes 3 , 4 , 5 , and 6 as aggregates built up by two, three, or nine MFl(DIGLYME) units, and compound 7 as a polymeric band.">

Synthesis, Characterization, ..

The relationship between exposure to EGEs and haematological effects has been evaluated in three occupational populations. In none of these studies was diglyme measured or used alone. In a cross-sectional study of 94 shipyard painters exposed to measurable levels of 2-ethoxyethanol and 2-methoxyethanol and 55 unexposed controls, Welch & Cullen (1988) found 10% of painters with haemoglobin levels consistent with anaemia ( = 0.02) and 3.4% of painters and no controls with abnormally low levels of polymorphonuclear leukocytes ( = 0.07). In a second cross-sectional study of 40 workers employed in the production of ethylene glycol monoether, the overall proportion of exposed workers with abnormal haemoglobin levels or white blood cell counts did not differ from unexposed controls ( = 25) (Cook et al., 1982). Controlling for potential age, duration, and intensity of exposure using logistic regression suggested a statistically significant decrease (27%) in white blood cell counts. A small study of nine individuals who laid parquet floors and matched pairs of healthy donors showed no changes in haemoglobin or erythrocyte levels but higher frequencies of NK-cells (anti-Leu7) and B lymphocytes (Denkhaus et al., 1986). Exposures included measurable concentrations of 2-butoxyethanol, 2-ethoxyethanol, 2-methoxyethanol, toluene, xylene, 2-butanone, and other solvents. No association was found between use of products containing glycol ethers and myeloid acute leukaemia in a study of 198 matched pairs (Hours et al., 1996).


Diglyme is also used in the manufacture of integrated circuit boards, primarily as a solvent for the photoresists. These are used as photosensitive materials for the coating of the wafer during microlithographic patterning in the photo/apply process (Messner, 1988; Correa et al., 1996; Gray et al., 1996) and in the production of semiconductors (Corn & Cohen, 1993).