Nuclear-Chemical Synthesis of 1,4-Diazine Quaternary Salts

In March 2015, NASA Ames researchers revealed that, out of the blue, complex DNA and RNA natural mixes of life, including uracil, cytosine and thymine, have been framed in the lab under space conditions, utilizing beginning chemicals, for example, pyrimidine, found in shooting stars. Pyrimidine, as polycyclic sweet-smelling hydrocarbons (PAHs), the most carbon-rich synthetic found in the universe, may have been shaped in red monsters or in interstellar clean and gas mists.

Synthesis of 1,4-Diazines by Ring Expansion of 1,3-Diazines

24/11/2017 · Synthesis of some β-trichloromethyl-azines and -diazines D

Synthesis of tritium-labelled biologically important diazines

N2 - Suzuki coupling of 5-chloro-2-methyl-6-phenylpyridazin-3(2H)-one, 6-chloro-1,3-dimethyluracil and 2-chloropyrazine with protected aminoaryl boronic acids resulted in the corresponding pivaloylaminophenyl diazines which were transformed to diazino-fused indole and cinnoline derivatives. Suzuki coupling of 5-amino-6-chloro-1,3-dimethyluracil with 2-formylphenyl boronic acid afforded a novel pyrimidoisoquinoline ring system in a one-pot reaction.

Synthesis of 1:4-diazines - Free Patents Online

AB - Suzuki coupling of 5-chloro-2-methyl-6-phenylpyridazin-3(2H)-one, 6-chloro-1,3-dimethyluracil and 2-chloropyrazine with protected aminoaryl boronic acids resulted in the corresponding pivaloylaminophenyl diazines which were transformed to diazino-fused indole and cinnoline derivatives. Suzuki coupling of 5-amino-6-chloro-1,3-dimethyluracil with 2-formylphenyl boronic acid afforded a novel pyrimidoisoquinoline ring system in a one-pot reaction.

T1 - 1,3-Dipolar cycloadditions in the synthesis of annelated diazines: design of new scaffolds for anticancer and antimicrobial agents
The diazines were synthesized by Suzuki coupling of 3-bromo-6-(thiophen-2-yl)pyridazine with commercially available (hetero)aryl-boronic acids.

Nuclear-Chemical Synthesis of 1,4-Diazine Quaternary …

Synthesis and antitumor studies of N 4-substituted thiosemicarbazones derived from acyl diazines

Syntheses and metalation of pyridazinecarboxamides …

Rhodium Thiavinyl Carbenes from 1,2,3-Thiadiazoles Enable Modular Synthesis ..

Thieme E-Journals - Synthesis / Volltext