Synthesis of Decitabine - Patent - Europe PMC
Efficacy of Lenalidomide in Myelodysplastic Syndromes …
Decitabine is believed to exert its antineoplastic effects after phosphorylation and direct incorporation into DNA and inhibition of DNA methyltransferase, causing hypomethylation of DNA and cellular differentiation or apoptosis. Decitabine inhibits DNA methylation which is achieved at concentrations that do not cause major suppression of DNA synthesis. Decitabine-induced hypomethylation in neoplastic cells may restore normal function to genes that are critical for the control of cellular differentiation and proliferation. In rapidly dividing cells, the cytotoxicity of decitabine may also be attributed to the formation of covalent adducts between DNA methyltransferase and decitabine incorporated into DNA. Non-proliferating cells are relatively insensitive to decitabine.
Jiricny, Nucleosides Nucleotides 6, 393 (1987)
Men should be advised not to father a child while receiving treatment with Decitabine for Injection, and for 2 months following completion of treatment Men with female partners of childbearing potential should use effective contraception during this time. Based on its mechanism of action, Decitabine for Injection alters DNA synthesis and can cause fetal harm.