Patent US8586729 - Synthesis of decitabine - Google …

The process development of 5-azacytosine-based nucleosides azacitidine and decitabine are described as a backdrop to a more detailed account of the discovery and development of cladribine, a chlorinated, deaminase-resistant derivative of the naturally occurring nucleoside, 2′-deoxyadenosine, that possesses both antineoplastic and immunosuppressive activity. To address the distinct challenges in the regio- and stereoselective syntheses of these molecules, and their stability, each process employs unique variations of the Vorbrüggen glycosylation for the key C-N bond-forming step.

Synthesis of Decitabine - Patent - Europe PMC

To Decitabine Synthesis - Globe Thesis

Efficacy of Lenalidomide in Myelodysplastic Syndromes …

Decitabine is believed to exert its antineoplastic effects after phosphorylation and direct incorporation into DNA and inhibition of DNA methyltransferase, causing hypomethylation of DNA and cellular differentiation or apoptosis. Decitabine inhibits DNA methylation which is achieved at concentrations that do not cause major suppression of DNA synthesis. Decitabine-induced hypomethylation in neoplastic cells may restore normal function to genes that are critical for the control of cellular differentiation and proliferation. In rapidly dividing cells, the cytotoxicity of decitabine may also be attributed to the formation of covalent adducts between DNA methyltransferase and decitabine incorporated into DNA. Non-proliferating cells are relatively insensitive to decitabine.

Jiricny, Nucleosides Nucleotides 6, 393 (1987)

Men should be advised not to father a child while receiving treatment with Decitabine for Injection, and for 2 months following completion of treatment Men with female partners of childbearing potential should use effective contraception during this time. Based on its mechanism of action, Decitabine for Injection alters DNA synthesis and can cause fetal harm.

To perform the quality control of decitabine,the α-stereoisomer was synthesized from 2-deoxy-D-ribose by methylation and ..
Title: Synthesis of decitabine

DNMT1 Gene - GeneCards | DNMT1 Protein | DNMT1 Antibody

Men should be advised not to father a child while receiving treatment with Decitabine for Injection, and for 2 months following completion of treatment. Men with female partners of childbearing potential should use effective contraception during this time. Based on its mechanism of action, Decitabine for Injection alters DNA synthesis and can cause fetal harm.

Based on its mechanism of action, Decitabine for Injection alters DNA synthesis and can cause fetal harm. Close. 6 ADVERSE REACTIONS. 6.1 Clinical Studies Experience.

Decitabine improves patient outcomes in …

The Development and Manufacture of Azacitidine, Decitabine, and Cladribine: Stereoselective Ribonucleoside Drug Synthesis Using the Vorbrüggen Glycosylation

this process can be reversed during DNA synthesis, ..