7.1.2 Dermal In the only dermal studies identified, LD50 values of > 1124 and > 2058 mg Cu/kg body weight per day were reported, the first for rats exposed to copper(II) oxysulfate (NIOSH, 1993) and the second for rabbits exposed to copper(II) hydroxide (Tomlin, 1994).

The hazards of copper(II) sulfate pentahydrate are described.

7.3.1 Oral Copper(II) sulfate The critical study is that of Hébert et al.

Copper(II) sulfate is a compound with the formula CuO 4 S

From the available information on copper(II) sulfate, rats appear to be less susceptible to copper than domestic animals; this pattern is also evident in studies involving repeated exposure (section 7.2).

Copper(II) sulfate pentahydrate is a sulfate salt of copper

In two studies involving the intratracheal instillation in rats of copper(II) oxide (Hirano et al., 1993) or copper(II) sulfate pentahydrate (Hirano et al., 1990) at doses of up to 0.1 or 0.05 mg Cu/rat, respectively (roughly 0.36 or 0.18 mg Cu/kg body weight), acute inflammatory changes were evident in the lungs from 0.018 mg Cu/kg body weight with the soluble sulfate salt and from 0.073 mg Cu/kg body weight with the insoluble oxide.

As was observed in the short-term studies (section 7.2), mice are markedly less sensitive than rats to the toxicity of copper(II) sulfate.

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When rat hepatocytes were incubated for 20 h with 7.9, 15.7, 31.4 or 78.5 µmol/litre copper(II) sulfate solution (the highest concentration being moderately cytotoxic), there was a significant increase in unscheduled DNA synthesis at each concentration in a roughly dose-related manner.

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Copper (II) sulfate, when studied in strains T98, T100 and TA102 of Salmonella typhimurium with and without metabolic activity, even at cytotoxic concentrations or the limit of solubility, did not exhibit mutagenic activity (Moriya et al., 1983; Marzin & Phi, 1985).

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Exposure to copper(II) sulfate induced effects on neonatal body weight, and on organ weights and biochemistry in mice at 1.3-1.6 mg Cu/kg body weight per day, while higher doses were embryolethal to mice (at 80 mg Cu/kg body weight per day) and to mink (at 12 mg/kg body weight per day).

In rats, oral exposure to copper(II) sulfate in two studies did not affect the results of behavioural tests, but did alter brain neurochemistry.

solutions of calcium nitrate and copper(II) sulfate

6.5.8 Other interactions (molybdenum, manganese, selenium) Dietary molybdenum, in the presence of sulfate, forms insoluble complexes with copper thereby decreasing the availability of copper for absorption.

Clams exposed to sediment mixed with a strong chelating agent and copper showed no significant change in burrowing time.

Copper sulfate is employed at a limited level in organic synthesis.

In the micronucleus test no evidence of genotoxic activity was found in mice given a single injection of copper(II) sulfate pentahydrate at 1.7, 3.4 and 5.1 mg Cu/kg body weight (Tinwell & Ashby, 1990).

Search results for Copper(II) sulfate at Sigma-Aldrich In vivo A single intraperitoneal injection of copper(II) sulfate pentahydrate in mice induced a dose-related increase in the incidence of chromatid type chromosome aberrations in the bone marrow 6 h after dosing between 0.28 and 1.7 mg Cu/kg body weight (Agarwal et al., 1990).