FOUR STAGES OF CHOLESTEROL SYNTHESIS
Cholesterol biosynthesis from lanosterol
A third molecule of acetyl CoA is added, producing HMG CoA, a six-carbon compound.
Synthesis of Mevalonate
~ The next step, the reduction of HMG CoA to mevalonate, is catalyzed by HMG CoA reductase.
~ It is the rate-limiting and key regulated step in cholesterol synthesis.
While cholesterol synthesis is mostly associated with eukaryotes, ..
In addition, we determined serum concentrations of lanosterol, a precursor of cholesterol and a possible indicator of cholesterol biosynthetic activity.
Steroidal Triterpenes of Cholesterol Synthesis - MDPI
Cholesterol is an important biochemical, medical, and commercial molecule. In the pathway for cholesterol biosynthesis, biochemistry textbooks discuss the synthesis of lanosterol from acetate in detail. However, the conversion of lanosterol to cholesterol is most often simply indicated as a multistep process, without elaboration. A pathway for the conversion of lanosterol to cholesterol, based on recent results from the primary research literature, is presented in this paper. Each reaction is discussed, the pathway is discussed within the context of general biochemical transformations, a summary of cholesterol homeostasis is presented, and enzyme deficiencies that give rise to diseases are given.