Synthesis, characterization and studies of new 3‐benzyl…

Hydrolysis studies of derivatives of molybdocene dichloride in which the two chloride ligands were replaced by 3,5-bis(trifluoromethyl)thiophenol, 3,5-bis(trifluoromethyl)benzyl thiol, and 2,2,2-trifluoro-ethane thiol ligands confirmed that the electron-withdrawing groups affect the lability of the Mo-S bonds and promote slow generation of the putative biologically active species "Cp2Mo2+"; the trifluoroethane thiol derivative underwent 50% hydrolysis in 14 h in 10% D2O/DMSO-d6. The structure

Reaction of Thiols | Thiol | Chemical Reactions

6 supplier|2-Methylthiophene-3-thiol|Custom synthesis - Evershine Professional manufacturer ...
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Large-Scale Thiol-Free Synthesis of Symmetrical ..

N2 - The synthesis and characterization of long-chain alkyltrichlorosilanes of alkyl halides, benzyl halides, and α-haloacetyls designed to form silozane-anchored self-assembled monolayers (SAMs) for the selective attachment of peptides (via cysteine thiols) is described. Thin film formation by the trichlorosilanes was demonstrated by spectroscopic means and by surface wetting properties. Halide exchange could be utilized to produce the more reactive (iodide) surfaces in situ, following their deposition in a more stable (chloride or bromide) form. In solution, these functional groups were found to have a range of reactivity with model thiols which extended from half-lives of minutes to days (essentially no reactivity). The order of reactivity is I > Br > Cl within each class of compounds, and α-haloacetyl > benzyl ≫ alkyl. The reactivity of the SAMs with thiols showed the same order of reactivity. The very reactive α-iodoacetyl was also reactive with amines, but competition experiments demonstrated preference for the thiol under our reaction conditions. SAM reactivity with cysteine-containing peptides was demonstrated with a tripeptide (glutathione) and a nonapeptide (laminin fragment). Both peptides show maximum attachment after 2-3 h of exposure to millimolar concentrations. The attachment was completely blocked by prior treatment of these peptides with dinitrophenylmaleimide or by air oxidation of the thiol. Given that these peptides contain all the nucleophilic side chains found in proteins (thiol, alcohol, phenol, carboxyl, and amine), the selective blocking experiments indicate that these SAMs will be useful for the directed attachment through cysteine side chains in proteins and peptides.

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“Synthesis and Electrochemical Properties of Benzyl-mercapto and Dodecyl-mercapto Tetrasubstituted Manganese Phthalocyanine Complexes.” 52.7 (2007): 2520–2526.

In the complex, the Hg cation binds to a C atom of a phenyl ring and the S atom of a benzyl­thiol­ate ligand in a linear coordination geometry.
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Search results for benzyl thiol at Sigma-Aldrich

AB - DOTA (1,4,7,10-tetraazacyclodocecane-N,N′,N″,N‴-tetraacetic acid), which forms extremely stable complexes with a large number of metal ions, is one of the most important and most commonly used chelators for in vivo applications such as cancer diagnosis and therapy. However, many of the published synthesis protocols for DOTA derivatives are complicated and give the products in low yields. Here we report improved synthesis routes for tris-tBu-DOTA, tris-benzyl-DOTA, and thiol-DOTA, and also describe the synthesis of the novel compound tris-4-nitro-benzyl-DOTA. In addition, we determined the applicability of the DOTA derivatives tris-tBu-DOTA, thiol-DOTA, tris-benzyl-DOTA, tris-4-nitrobenzyl-DOTA, tris-allyl-DOTA, DOTA-PFP-ester, and DOTA-PNP-ester for multimerization reactions using amino functionalized PAMAM dendrimers of different sizes. Thiol-DOTA was found to be the best compound for efficient reactions with dendritic scaffolds generating highly homogeneous DOTA-multimers. This DOTA derivative could be quantitatively conjugated to a 128-mer dendrimer.

Fukuyama, Synthesis, 2002, 1121-1123

AB - The synthesis and characterization of long-chain alkyltrichlorosilanes of alkyl halides, benzyl halides, and α-haloacetyls designed to form silozane-anchored self-assembled monolayers (SAMs) for the selective attachment of peptides (via cysteine thiols) is described. Thin film formation by the trichlorosilanes was demonstrated by spectroscopic means and by surface wetting properties. Halide exchange could be utilized to produce the more reactive (iodide) surfaces in situ, following their deposition in a more stable (chloride or bromide) form. In solution, these functional groups were found to have a range of reactivity with model thiols which extended from half-lives of minutes to days (essentially no reactivity). The order of reactivity is I > Br > Cl within each class of compounds, and α-haloacetyl > benzyl ≫ alkyl. The reactivity of the SAMs with thiols showed the same order of reactivity. The very reactive α-iodoacetyl was also reactive with amines, but competition experiments demonstrated preference for the thiol under our reaction conditions. SAM reactivity with cysteine-containing peptides was demonstrated with a tripeptide (glutathione) and a nonapeptide (laminin fragment). Both peptides show maximum attachment after 2-3 h of exposure to millimolar concentrations. The attachment was completely blocked by prior treatment of these peptides with dinitrophenylmaleimide or by air oxidation of the thiol. Given that these peptides contain all the nucleophilic side chains found in proteins (thiol, alcohol, phenol, carboxyl, and amine), the selective blocking experiments indicate that these SAMs will be useful for the directed attachment through cysteine side chains in proteins and peptides.

Benzyl Ethers - Organic chemistry

Its molecular structure is similar to p-Aminobenzoic acid (PABA) which is needed in bacteria organisms as a substrate of the enzyme dihydropteroate synthetase for the synthesis of tetrahydrofolic acid (THF).