New Method for the Synthesis of Ether Derivatives of ..

Together with its semi synthetic derivatives, artemisinin not only lack cross-resistance with other antimalarials but also has the remarkable ability to induce a 10 000 fold reduction in parasitemia.

for synthesis of other ether derivatives ..

 Stereoselective synthesis and antimalarial activity of alpha-artelinic acid from artemisinin

scale synthesis of ether derivatives of artemisinin

AB - Novel hybrids of non acetal and acetal-type derivatives at C-12 of artemisinin and glycolipids were synthesized via efficient coupling reactions. Some of these hybrids showed potent in vivo antiangiogenic activity on the chorioallantoic membrane (CAM) that was higher than or comparable to those of fumagillin and thalidomide at a concentration of 2.5 nmol.

a new kind of artemisinin derivatives with piperazino group ..

Malaria is a serious and common problem among travellers all over the world especially travellers travelling to Indonesia. This descriptive study focus on artemisinin-based therapy for malaria especially in Indonesia. According to Centers for Disease Control (CDC), malaria is still present in most part of Indonesia. In April 2001, WHO recommended the use of artemisinin-based combination therapies (ACTs) to minimize the burden caused by resistance to conventional anti-malarial medications. Artemisinin is a sesquiterpene lactone produced from a plant called It is active against all Plasmodium species and its able to destroy all the blood stages of the parasite. Artemisinins causes less toxic effect if compared with other antimalarial agents. The year 2004 marks the beginning of adoption of artemisnin-based combination therapies (ACTs) into national malaria control program in Indonesia. 3 types of ACT which are dihydroartemisinin-piperaquine, artemether-lumefantrine andartesunate-amodiaquine. have been used recently to treat uncomplicated malaria in Indonesia. Resistance to artemisinin and its derivatives has been recently reported from Thailand-Cambodia border.

" Stereoselective synthesis and antimalarial activity of alpha-artelinic acid from artemisinin "

PubMed - National Center for Biotechnology Information

This review of rectally administered artemisinin derivatives for malaria treatment concluded that they demonstrated acceptable therapeutic efficacy, including in severe illness. The reliability of this conclusion was unclear as some aspects of the review, including the synthesis and validity assessment, were poorly reported and potentially inappropriate.

" Artemisinin derivatives with 12-aniline substitution: synthesis and antimalarial activity "

Novel ferrocenic artemisinin derivatives: synthesis ..

Controlled studies used comparators of parenteral quinine, artemether or artesunate. Approximately half the included studies were in children, others enrolled only adults or both children and adults. The severity of malaria ranged from uncomplicated to severe. A range of doses and regimens of artemisinin derivatives were employed.

Fully synthetic artemisinin derivatives have also ..

Studies which assessed rectal administration of an artemisinin derivative in healthy volunteers or patients of any age, regardless of malaria (Plasmodium) parasite species or clinical status, were eligible for inclusion. To be included, participant details had to be clearly specified, with either plasma drug concentrations or parasite clearance assessed using serial blood smears taken at least every 6 hours. Primary outcomes were malaria parasite density as a percentage of baseline at 12 and 24 hours, and time to 50% reduction in parasitaemia. Secondary outcomes were total parasite clearance time, mortality and adverse events.

NEW SERIES OF ARTEMISININ DERIVATIVES AND …

Damage includes swelling and deformity of food vacuoles membrane, nuclear membrane, endoplasmic reticulum and formation of autophagic vacuoles.
It is also proposed that β arteether inhibits the protein synthesis and alters the ribosomal organization and endoplasmic reticulum. CONTRAINDICATIONS
β arteether injection is contraindicated in patients hypersensitive to artemisinin derivatives Dosage: Adult: 150mg i.e.