for synthesis of other ether derivatives ..
scale synthesis of ether derivatives of artemisinin
AB - Novel hybrids of non acetal and acetal-type derivatives at C-12 of artemisinin and glycolipids were synthesized via efficient coupling reactions. Some of these hybrids showed potent in vivo antiangiogenic activity on the chorioallantoic membrane (CAM) that was higher than or comparable to those of fumagillin and thalidomide at a concentration of 2.5 nmol.
a new kind of artemisinin derivatives with piperazino group ..
Malaria is a serious and common problem among travellers all over the world especially travellers travelling to Indonesia. This descriptive study focus on artemisinin-based therapy for malaria especially in Indonesia. According to Centers for Disease Control (CDC), malaria is still present in most part of Indonesia. In April 2001, WHO recommended the use of artemisinin-based combination therapies (ACTs) to minimize the burden caused by resistance to conventional anti-malarial medications. Artemisinin is a sesquiterpene lactone produced from a plant called It is active against all Plasmodium species and its able to destroy all the blood stages of the parasite. Artemisinins causes less toxic effect if compared with other antimalarial agents. The year 2004 marks the beginning of adoption of artemisnin-based combination therapies (ACTs) into national malaria control program in Indonesia. 3 types of ACT which are dihydroartemisinin-piperaquine, artemether-lumefantrine andartesunate-amodiaquine. have been used recently to treat uncomplicated malaria in Indonesia. Resistance to artemisinin and its derivatives has been recently reported from Thailand-Cambodia border.
PubMed - National Center for Biotechnology Information
This review of rectally administered artemisinin derivatives for malaria treatment concluded that they demonstrated acceptable therapeutic efficacy, including in severe illness. The reliability of this conclusion was unclear as some aspects of the review, including the synthesis and validity assessment, were poorly reported and potentially inappropriate.