A., One-Pot Synthesis of Polyfunctionalized Cyclic Urea Derivatives.

It was soon realized that in the diazo reaction different combinations of atomic groupings could be introduced. The combinations seemed infinite and many thousands of experiments were undertaken. Not many commercial azo dyes resulted, but those that were successful made massive contributions to the balance sheets and fueled the demand for more research. New intermediates were introduced, including aniline in which amino group hydrogens had been substituted, and hydroxy and amino derivatives of naphthalene. When the amino compounds of toluene were introduced redder dyes were created.

Synthesis description for preparation of ANILINE

Preparation of Aniline Derivatives: ..

N2 - A series of 2,3,4,9-tetrahydrofuro[2,3-b]quinolin-3,4-dione and ethyl 2-(substituted aniline)-4-oxo-4,5-dihydrofuran-3-carboxylate were synthesized and evaluated for cytotoxicity on murine leukemia WEHI-3 cells. The cytotoxic effects of most compounds tested were dose-dependent and the structure-activity relationships indicated that N-substituted benzyl derivatives displayed a stronger inhibitory activity against murine leukemia WEHI-3 cells compared to non-N-substituted benzyl substituted derivatives.

A Concise Synthesis of Substituted Thiourea Derivatives …

AB - A series of 2,3,4,9-tetrahydrofuro[2,3-b]quinolin-3,4-dione and ethyl 2-(substituted aniline)-4-oxo-4,5-dihydrofuran-3-carboxylate were synthesized and evaluated for cytotoxicity on murine leukemia WEHI-3 cells. The cytotoxic effects of most compounds tested were dose-dependent and the structure-activity relationships indicated that N-substituted benzyl derivatives displayed a stronger inhibitory activity against murine leukemia WEHI-3 cells compared to non-N-substituted benzyl substituted derivatives.

Synthesis of New Tetrazole and Triazole Substituted Pyroglutamic Acid and Proline Derivatives.

Search results for aniline derivatives at Sigma-Aldrich

N-Allylation of o-tert-butyl anilides derived from o-tert-butyl aniline and (S)-lactic acid or (S)-mandelic acid proceeded with high diastereoselectivity in the presence of a (BINAP)Pd-π-allyl catalyst to give atropisomeric N-allyl o-tert-butyl anilide derivatives.

A green one-pot multicomponent synthesis of 4H …

CONCLUSIONS: Quinoline and its derivatives are important heterocyclic systems which have great significance as a biologically active compounds as well as being useful synthon for synthesis of many heterocyclic compounds. This work describes the synthesis of new heterocyclic compounds from quinoline derivatives and amines.

Gould-Jacobs reaction starting from an aniline and ethyl ..

In view of significant interest in the synthesis of these heterocyclic, we herein report in a detailed account of the synthetic methods available for the synthesis of (12). In a typical experiment, aniline, dimethyl acetylenedicarboxylate (DMAD) and benzaldehyde were reacted in presence of p-toluene sulfonic acid in absolute ethanol with stirring to afford the corresponding product, dimethyl (2R,3S,4R)-2-phenyl-4-(phenylamino)- 1, 3, 4-tryhydroquinoline-2,3-dicarboxylate (12) in moderate yield. The reaction was completed within 72 hours, as it can be seen below:

M., Synthesis and functionalization of cyclic poly(hydroxystyrene) derivatives.

quinoline derivatives were synthesized from reaction of aniline, ..

AB - N-Allylation of o-tert-butyl anilides derived from o-tert-butyl aniline and (S)-lactic acid or (S)-mandelic acid proceeded with high diastereoselectivity in the presence of a (BINAP)Pd-π-allyl catalyst to give atropisomeric N-allyl o-tert-butyl anilide derivatives.

Synthesis of Benzylamine and Derivatives - Erowid

N2 - N-Allylation of o-tert-butyl anilides derived from o-tert-butyl aniline and (S)-lactic acid or (S)-mandelic acid proceeded with high diastereoselectivity in the presence of a (BINAP)Pd-π-allyl catalyst to give atropisomeric N-allyl o-tert-butyl anilide derivatives.

Catalyst-free synthesis of pyrazole-aniline linked ..

Alizarin, like quinine and many potential novel dyes, was, from around 1850 considered to be related to coal tar compounds. Analysis indicated that the starting point for alizarin might be naphthalene. Indeed, once the aniline colors appeared, synthesis of alizarin from naphthalene was investigated in Germany, France and Britain. However, no useful products appeared. The breakthrough occurred in 1867 at the Gewerbe Institute, a trade college in Berlin. There since 1860, Adolf Baeyer had undertaken research into natural products, and had shown a keen interest in indigo and alizarin. His assistant Carl Graebe established that alizarin was probably a quinone, and went on, with Carl Liebermann to show that it was a derivative of anthracene, and not naphthalene. Alizarin was, as they demonstrated in 1868, a dihydroxyanthraquinone.[21] Synthesis was achieved by bromination of anthraquinone, followed by hydrolysis.