Synthesis of a new iron tricarbonyl ..
One Pot Synthesis of Alpha-Aminonitrile and Alpha …
The functional data and the fact that NF-E2 sites are found in association with this constellation of genes involved in red cell development, suggests that NF-E2 coordinates hemoglobin production by regulating the expression of globin proteins, heme biosynthesis and iron uptake (Andrews, 1994).
One Pot Synthesis of Alpha-Aminonitrile and Alpha ..
NF-E2 recognition elements are also found in the promoters for red cell-specific forms of the heme biosynthetic enzymes porphobilinogen deaminase and ferrochelatase (Mignotte et al., 1989); (Taketani et al., 1992). Interestingly, forced expression of p45 NF-E2 in non-erythroid cells stimulates iron uptake (Chang and Andrews, in preparation).
Alpha-thalassemia - there is deficient synthesis of alpha globin.
The level of iron uptake is sufficient for cell division but not hemoglobin synthesis (Shannon et al., 1986). Beug and co-workers demonstrated that an anti-transferrin receptor monoclonal antibody to chick erythroid cells blocked erythroid differentiation at the erythroblast or early reticulocyte stage, and promoted premature, pyknotic cell death (Schmidt et al., 1986).
Amino acid synthesis - Wikipedia
Chelators may also induce apoptosis or programmed cell death (Fukuchi et al., 1994). Erythroid precursors need an extraordinary amount of iron to support hemoglobin synthesis and differentiation into mature red cells.
Battle Resort - Pokemon Omega Ruby and Alpha ..
Obese individuals also have low levels of iron. The reason for this is not known because unlike vitamin D, iron would not be stored in the fat cells. Iron is best known as a cofactor in haemoglobin, where it is required to transport oxygen in the blood. However, it also acts as a cofactor in the tyrosine hydroxylase enzyme, and low iron status may therefore be associated not only with poor oxygen transport, but also with a reduced synthesis of dopamine.