V., Synthesis of substituted 1,2,3-triazoles via -sulfonylaziridines.
V., Synthesis of (azidomethyl)phenylboronic acids.
The isocyanate groups are highly reactive functional groups and can react with hydroxyl and amino groups to form urethane and urea structures, therefore, acyl azide chemistry has been paid much attention in organic synthesis and organic reactions.
R., Efficient Synthesis of Azide-Bearing Cofactor Mimics.
However, due to the instability of acyl azide monomers to heat and light, we noticed that quite a few papers were published on preparation of polymer by chain polymerization of unsaturated acyl azides as monomers.
"Synthesis of Alkyl Azides with a Polymeric ..
A classic method for the synthesis of azides is the Dutt-Wormall reaction in which a reacts with a first to a diazoaminosulfinate and then on the azide and a .
Organic & Inorganic Azides: Definition, Reactions & …
Organic azides engage in useful . The terminal nitrogen is mildly nucleophilic. Azides easily extrude diatomic , a tendency that is exploited in many reactions such as the or the or for example in the synthesis of γ-imino-β-enamino esters.
Azides: their preparation and synthetic uses
Azides may be reduced to by or with a phosphine, e.g. , in the . This reaction allows azides to serve as protected -NH2 synthons:
Reduction of Azides to Amines or Amides With Zinc …
The pivaloate ester was then cleaved using sodium methoxide, and the resulting alcohol oxidised using the Piancatelli conditions. Next followed a rather interesting sequence to install the nitrogen atom which would ultimately be used to form the azetidine present in the natural product. Thus, when the enal was treated with TMSCN and DBU the cyanohydrin TMS ether was formed, which then underwent isomerisation to the α-trimethylsiloxy vinyl cyanide before conversion to the acyl cyanide. This was quenched with allyl alcohol to give the expected ester, obtained as 4:1 mixture of epimers in favour of the desired axial product. Deallylation using Pd(PPh3)4 and pyrrolidine as the nucleophile gave the acid that was then converted, via the acid chloride, to the acyl azide. Heating of this compound in benzyl alcohol effected a Curtius rearrangement to give the Cbz protected amine in good yield.