Synthesis of Acetanilide by Valeria Osses on Prezi
Preparation/Recrystallization of Acetanilide | MendelSet
Synthesis of Acetanilide was started from aniline and acetic anhydride via a nucleophilic acyl substitution reaction to form acetanilide and acetid acid under water (base).Under a basic condition, the free electrons in amine(aniline) attracts the C2 of Acetic anhydride (carbonyl group of acyl compound) and formed tetrahedral intermediate. The leaving group acetate was reppled by reforming of keton. The free electon on H2O attract the H in NH2+ cation and formed H3O+,and left product acetanilide. Also the acetate pulled a proton from H3O+ to form acetid acid, while the H3O+ was going back to be H2O.
Synthesis of Acetanilide - YouTube
Aniline(2 ml,2.06 g,22.1 mmol), Acetic anhydride(3 ml,3.24 g,31.7 mmol), and distilled water(15 ml,15 g, 0.832 mol) were combined and stirred 30 minutes. Upon completion, the product was dried by porcelain Buchner funnel and ice-cold water(2 ml) was used to wash product for 20 minutes to dry off solvent. Remaining white power was desired product. The melting point of pure acetanilide should be the range from 113 C to 115 C.