2,4,6-trihydroxyacetophenone | Sigma-Aldrich

2',4',6'-Trihydroxyacetophenone, Monohydrate, also known as 2-Acetylphloroglucinol or THAP, is a phloroglucinol with a plasma cholesterol-lowering activity. Ungraded products supplied by Spectrum are indicative of a grade suitable for general industrial use or research purposes and typically are not suitable for human consumption or therapeutic use. These materials may or may not have a Certificate of Analysis available.

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in better sensitivity than 2,4,6-trihydroxyacetophenone (2,4,6-THAP) using MALDI-TOF.

2,4,6-trihydroxyacetophenone, 480-66-0 - The Good …

AB - Desmosdumotin C (1), a novel compound isolated from the roots of Desmos dumosus, was synthesized from 2,4,6-trihydroxyacetophenone (2), confirming the assigned structure of the natural product.

2',4',6'-Trihydroxyacetophenone monohydrate CAS 480 …

N2 - Desmosdumotin C (1), a novel compound isolated from the roots of Desmos dumosus, was synthesized from 2,4,6-trihydroxyacetophenone (2), confirming the assigned structure of the natural product.

in better sensitivity than 2,4,6-trihydroxyacetophenone (2,4,6-THAP) using MALDI-TOF.

Buy 2,4,6-Trihydroxyacetophenone monohydrate …

When the reaction of arylmethylidenepyruvic acids 1, 1,3-cyclohexandiones 2 and ammonium acetate 3 was performed by abrasion in a mortar without using any solvent or catalyst at room temperature, high yields of 5-oxo-4-phenyl-1,4,5,6,7,8-hexahydro-2-quinolinecarboxylic acid derivatives were obtained ().

Synthesis of (±)-farnesyl flavanone and farnesyl acetophenone

The recent focus on the green chemical theme of eliminating the use of solvents also encouraged us to extent our studies to neat reaction conditions [26-34]. In this article, we report a very simple, efficient and clean synthetic route to 5-oxo-4-phenyl-1,4,5,6,7,8-hexahydro-2- quinolinecarboxylic acid derivatives via three-component reaction of arylmethylidenepyruvic acids, 1,3-cyclohexandiones and ammonium acetate in solvent-free reaction condition. Moreover, the produced target compounds as heterocyclicα-amino carboxylic acids can be of interest for the synthesis of novel peptides containing a heterocyclic moiety in their skeleton, which could lead to some biologically active compounds. On the other hand, these compounds can be used as an efficient starting material for further multicomponent reactions, because of the possession of both amine and carboxylic acid functional groups.

. The proposed mechanism for the synthesis of 5-oxo-4-phenyl-1,4,5,6,7,8-hexahydro-2-quinolinecarboxylic acids in solvent-free conditions.

Custom Synthesis Process R&D and CMO

The structures of compounds 4a - 4f were deduced from their spectroscopic data, which displayed in each case, the molecular ion peak at the appropriate m/z values. All of the products exhibited a singlet in 1H-NMR at about δ = 4.49 - 4.59 ppm for H-4 and also a distinguished peak at 36.2 - 36.8 ppm for C-4 in 13C-NMR spectroscopy. Meanwhile, 1H-NMR spectra of compounds 4d-f shows two doublets at 2.20 - 2.40 ppm with J = 16 Hz that is related to geminal coupling of H-6 protons. Selected spectroscopic data are reported.

. Synthesis of -oxo-4-phenyl-1,4,5,6,7,8-hexahydro-2-quinolinecarboxylic acids 4a - 4f in solvent-free conditions.

2',4',6'-Trihydroxyacetophenone, Monohydrate | 480 …

In conclusion, we have found that the abrasion of arylmethylidenepyruvic acids, 1,3-cyclohexandiones and ammonium acetate leads to a facile synthesis of 5-oxo-4- phenyl-1,4,5,6,7,8-hexahydro-2-quinolinecarboxylic acids without the addition of any catalysts under solventfree conditions at room temperature. Besides the simplicity of the method, our synthesized heterocyclic molecules have the potential to be biologically active or used as precursor to produce other biological active compounds. Further investigation about using of these products for the synthesis of novel peptides is going on our laboratory.

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2',4',6'-Trihydroxyacetophenone Monohydrate 98%, …

In order to apply this reaction to a library synthesis, various kinds of arylmethylidenepyruvic acids and 1,3- cyclohexandiones were subjected to give the corresponding 5-oxo-4-phenyl-1,4,5,6,7,8-hexahydro-2-quinolinecarboxylic acids 4, and representative examples are shown in .