2-Methyl-1-butene (disubstituted)

In addition, the Order for phenoxymethyl oxirane would also maintain the requirement for notification of use of the substance in any other activities not involving consumer products or cosmetics above the notification threshold of 100 kg.

3-Methyl-1-butene (monosubstituted)

This is the carbocation that leads to the observed product, 2-chloro-2-methylbutane.

Capture of this carbocation by chloride gives 2-chlorobutane.

A number of case reports describe the use of diazepam primarily for the management of muscle fasciculation. In one of the earliest case reports of the use of diazepam in organophosphorus insecticide poisoning (Barckow et al. 1969), three victims of parathion exposure were treated with a number of drugs including atropine and obidoxime; two patients received diazepam for muscle fasciculation. Likewise, Vale & Scott (1974) used diazepam to suppress the muscle fasciculation induced by occupational poisoning with demeton-S-methyl. Jovanoviiazepam (Merrill & Mihm, 1982). In this case, although the patient showed muscle fasciculation, she did not convulse. Since the subsequent course was prolonged and indicative of severe intoxication, the absence of convulsions may have been due to the co-ingestion of diazepam.

2-Methyl-1-butene Hydrogenchloride Tertiary carbocation Chloride

The Notice of Intent (NOI) is an opportunity for the public to comment on proposed amendments to the Domestic Substances List (DSL), to vary the significant new activity (SNAc) requirements of the Canadian Environmental Protection Act, 1999 (CEPA), for 24 substances and to rescind the SNAc requirements for 2 substances, pursuant to subsection 87(3).


9. Column 2 of Part 2 of the Domestic Substances List, opposite the reference to the substance “1314-62-1 S′” in column 1, is proposed to be replaced by the following:

3-Methyl-1-butene (monosubstituted double bond; least reactive)

In order to minimize the availability of products to consumers at concentrations of concern, the notification threshold for the manufacturing of consumer products containing these substances is proposed to be aligned with the safety data sheet (SDS) disclosure concentration threshold. For most substances, these concentration thresholds are set at either ≥0.1% or ≥1.0%, depending on the hazard class. In the case of methyl eugenol, the proposed concentration threshold is ≥0.0002% to align with the limit set by the Pest Management Regulatory Agency for methyl eugenol in pest control products applied to the skin and with Health Canada’s Cosmetic Ingredient Hotlist entry that describes a limit of 0.0002% for methyl eugenol in other leave-on and oral hygiene products.

2-Methyl-1-butene (disubstituted double bond)

Johnson MK & Vale JA (1992) Clinical management of acute organophosphate poisoning: an overview. In: Clinical and experimental toxicology of organophosphates & carbamates. In: Ballantyne B & Marrs TC eds. Oxford, Butterworth-Heinemann, pp 528-535.

Hydrogen bromide HBr 1,2-Dibromopropane

Batzinger RP, Ou SY, & Bueding E (1978) Antimutagenic effects of 2(3)-tert-butyl-4-hydroxyanisole and of antimicrobial agents. Cancer Res, 38: 4478-4485.

Hydrogenbromide Ethylidenecyclohexane (1-Bromoethyl)cyclohexane

12. Column 2 of Part 2 of the Domestic Substances List, opposite the reference to the substance “3445-11-2 N-S” in column 1, is proposed to be replaced by the following:

1-Bromo-2-methylbutane Hydrogenbromide 2-Methyl-1-butene

Churchill L, Padzernik TL, Cross RS, Giesler MP, Nelson SR, & Samson FE (1987) Cholinergic systems influence local cerebral glucose use in specific anatomical areas: diisopropyl phosphorofluoridate versus soman. Neuroscience, 20: 329-340.