Synthesis and Characterization of Some Metal Complexes of Vitamin C.

Mn(II), Cr(III), Co(II), Ni(II), Cu(II) and Zn(II) transition metal ions form solid chelates with VER drug molecule. The VER drug, in comparison to its metal complexes is also screened for its biological activity against Gram positive bacterial (Staphylococcus aureus) and Gram negative bacteria (Escherichia coli) and fungi (Candida albicans and Aspergillus flavus) in-vitro. Biological activity against Gram-positive bacteria follow the order as ZnL2 > NiL2>CoL2> CuL2 >MnL2 = CrL2> VER drug.

Synthesis and characterization of some metal- vitamin C complexes.

Compound 1 is a unique helical metal−cfH complex containing three types of helices.

Ofloxacin Metal Complexes: Synthesis, Characterization, Analytical ..

In this review, a summary of the metal complexes which has shown auspicious results has been conversed. Metal complexes proposed a platform for the design of novel therapeutic compounds. The activity of the compound can be increased by the formation of a complex with the different metal ion. It seems that opportunities exist to develop metal and metal-based drug candidates in the discovery and development of novel therapeutic agents. The encouraging results of preclinical and clinical studies with metal compounds form the basis for further investigations towards the development of metal complexes for the better therapeutic profile. Although metal complexes have some side effects, they are successfully being used in cancer therapy and several other therapies. Therefore there is a need for new approaches that are required to circumvent these drawbacks and pave a way for potent drug therapies.

Ofloxacin Metal Complexes: Synthesis, ..

The growth of conflict to anticipated chemotherapeutic drugs shown by some bacteria and fungi has serious insinuations for the sustained success of conventional antibacterial and/or antifungal therapy. However, some transition metal complexes of 1,10–phenanthroline epitomize a novel set of highly active antimicrobial agents whose approach of action is challengingly different to that of the prescription drugs. Hence, by supervisory their selective toxicity or devising appropriate pharmacological properties, they may be used either in combination with existing drugs or where resistance to conservative drugs has emerged.

Metal-bithiourea complexes: Synthesis, characterization and biological studies.
Synthesis, characterization and antibacterial activity of aspirin and paracetamolmetal complexes.

Fluoroquinolones: Synthesis and ..

- show the results of ALP, ALT and AST activities on the serum, kidney and liver. There was no significant reduction (p). The observed significant increase in the ALP activities in the liver and kidney of the rat administered with metal complexes suggests an enhancement of the activities of the existing enzymes by the drugs and their metabolites. The increase may be as a result of stress imposed on the tissue by the drug, which may lead to loss of the enzyme molecule through leakage into extra-cellular fluid, which has been significantly noticed in the serum. In a bid to offset this stress, the tissue may increase the de novo synthesis of the enzyme, thus accounting for the increase in activities in these tissues ().

Synthesis, characterization and antimicrobial activities of some nicotinamide-metal complexes.

Three kinds of ciprofloxacin metal ion coordination compound ..

The ligands exhibited MICs in the range of 0.75-1.5 mg/mL. The Mn(II) complex of H1L2 showed effective antibacterial activity against B. subtilis (MIC, 0.09 mg/ml). Complexes of Mn(II) and Cu(II) showed moderate inhibitory activity against the pathogens (MIC 0.18-0.37 mg/mL)21.Several studies reported that the metal complexes of divalent cations are more toxic than their metallic forms, particularly when compared to their own inorganic equivalents22. It may be due to chelation of metal because chelation reduces the polarity of the central metal ion by partial sharing of its positive charge with the donor groups. This increases the lipophilic nature of the metal ion, which in turn favors its migration into the lipid layer of the membrane.

Synthesis and antibacterial studies of mixed metronidazole-vitamin c metal complexes.

Fluoroquinolone–metal complexes: ..

Sobha et al. [25] studied the in vitro antibacterial activities of Schiff base and its mixed ligand Cu(II), Ni(II), Co(II) and Zn(II) complexes using a tryptophan-derived Schiff base (obtained by the condensation of tryptophan and benzaldehyde) as primary ligand and 1,10-phenantroline as the co-ligand. The Schiff base and its mixed ligand complexes have been assayed by the disc diffusion method for antibacterial activity against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli, Bacillus subtilis and Salmonella typhi. It is found that all the metal complexes have greater inhibitory effects than the free ligand. The higher antibacterial activities of the metal complexes compared to the Schiff base may be due to the changes in structure that occur due to coordination and chelation that causes the metal complexes to act as more powerful antibacterial agents.