Klein Ch12 | Alkene | Organic Synthesis
Ch27 : Synthesis of amino acids
1b) Via arylethanolamine methyl ester (with NaproxenResolution):Step 1:Yield 70-75%Step 2:
Yield 80% Crude (aprox)Step 3:Yield 75-82%Step 4:Yield 70%Step 5 + 6:Step 7+8:
Naproxen: (+)-6-Methoxy--methyl-2-naphthaleneaceticacid, CH3OC10H6CH(CH3)CO2H
Two steps, Total Yield 15%, 86.4%ccStep 9:
Many different resolution targets can be used to produce pure R-salbutamolincluding, as in the second synthesis, a racemic mixture of salbutamolits self.
which is a common reagent in organic synthesis
Welcome to Steve Ley’s research group webpages. Our laboratories, the Whiffen and Innovative Technology Centre are in the Department of Chemistry at the University of Cambridge. Here you’ll find out about our current research in flow chemistry and organic synthesis, as well as a look back at our historical achievements in natural product synthesis. We’re always keen to host academic and industry visitors and you are invited to get in touch.
Program Synthesis for Character Level Language ..
His preparation of tropinone is a competent but long synthesis which demonstrates one of the fundamental difficulties involved in the preparation of complex organic molecules. Although the individual steps in the synthesis generally give good to excellent yields, there are many of them which means that the overall yield becomes diminishingly small, of the order of 1%. As a result the early steps in the synthesis have to be carried out on inconveniently large quantities of material, and despite this, usually have to be repeated several times in order to obtain sufficient material to carry out the later stages on an acceptable scale.