Physical and Chemical Properties,Synthesis and Reactions

Kategaonkar et al, reported an efficient and novel one-pot synthesis of new 3, 4-dihydro-3-substituted-2H-naphtho[2,1-e][1,3]oxazine derivatives from 1-naphthol, various anilines and formalin at room temperature grinding is presented. The six-membered N, O-heterocyclic skeleton was constructed via zirconyl(IV) chloride promoted Mannich type reaction. In vitro antimicrobial activities of synthesized compounds have been investigated against Gram-positive Bacillus subtilis, Gram negative Escherichia coli and two fungi Candida albicans and Aspergillus niger in comparison with standard drugs. The results of preliminary bioassay indicate that some of title compounds possess significant antibacterial and antifungal activity 33.

Synthesis and Versatile Reactions of β-Azidotetraarylporphyrins.

T1 - Synthesis and ring transformation of novel tetracyclic fused as-triazines

L., The Convergence of Synthetic Organic and Polymer Chemistries.

ABSTRACT: A new series of s- triazine based chalcones have been synthesized by the temperature controlled reaction. The first substitution occurs at low temperatures (0°C), the second substitution at approximately at room temperature (25-30°C) and the third at elevated temperatures (70-100°C). This property allows substitution of three different neucleophiles onto the same triazine core which provides a vast array of possible triazine derivatives.

Synthesis of 1,3,5-triazines - Organic Chemistry Portal

A selective way to obtain disubstituted 1,2,4-triazines in good yields by combining addition reactions and palladium-catalyzed cross-coupling reactions of organometallics with 3-methylsulfanyl-1,2,4-triazine is described.

Multi-Site Modification of Neomycin B: Combined Mitsunobu and Click Chemistry Approach.

Inorganic Chemicals and Reactions; ..

The present survey has clearly demonstrated that Imidate may be successfully used to synthesize a wide variety of heterocycles of academic and pharmaceutical interest. Moreover, in general, the desired compounds may be obtained in a single stepwith high yield.

benzo[1,2,4]-triazines with aromatic aldehydes gave stable iminium ..

Poissonnet G. A simple and convenient synthesis of 1, 2-benzoxazoles via intramolecular mitsunobu reaction from salicylaldoximes and orthohydroxyarylketoximes. Synth Commun 1997;27(22):3839-46.

In the Pinner triazine synthesis ..

Ito Y, Ito I, Hirao T, Saegusa T. Synthetic reactions by complex catalysts XXXV. A facile synthetic method of cyclic imino ethers and imino thioethers. Synth Commun 1974;4(2):97-103.

Synthesis of N -Heterocycles - Organic Chemistry Portal

17. Camarero JA, Kwon Y, Coleman MA. Chemoselective attachment of biologically active proteins to surfaces by expressed protein ligation and its application for "protein chip" fabrication. 2004;126:14730-1

Synthesis of nucleosides - Organic Reactions Wiki

27. Panek JS, Zhu B. Synthesis of aromatic 1,2-diazines by inverse electron demand Diels-Alder reaction of polymer-supported 1,2,4,5-tetrazines. 1996;37:8151-4

A classical synthesis is also the Bamberger triazine synthesis

According to Ramjith et al, flouro, chloro 2-acetyl benzimidazole were prepared by the microwave induced reaction between 3-chloro-4-fluorobenzene-1, 2- diamine and lactic acid, followed by oxidation with potassium permanganate and aluminum oxide. The chalcone derivative of fluoro, chloro-2-acetyl benzimidazole were prepared by the condensation with different aldehydes and the resulting compounds were cyclized with thiourea, to get the thiazine derivatives of fluoro, chloro benzimidazole. The synthesized compounds have been characterized and confirmed by TLC, elemental analysis, IR, and 1H NMR spectroscopy and screened for their antibacterial and analgesic activity. Compounds containing electron withdrawing groups in the substituted Benzimidazole thiazine were found to show potent analgesic and antibacterial activities 21.