synthesis of water-soluble and biocompatible ..

A new sulfurizing reagent must, therefore, exhibit all the good properties of Beaucage Reagent while adding good stability in solution on the synthesizer AND offering strong ability to sulfurize RNA linkages. We are happy to offer Sulfurizing Reagent II, 3-((Dimethylamino-methylidene)amino)-3H-1,2,4-dithiazole-3-thione, DDTT (2). Use of Sulfurizing Reagent II in RNA Synthesis

Synthesis and Characterication of Water-Soluble ..

and Gao, M.,

Preparation of water soluble and biocompatible AIE …

Maibelin Rosales is Ph.D. candidate in Materials Science program of University of Chile. She works in the design and synthesis of oxide-metal nanomaterials with controlled morphology and structural dimensionality such as 0D, 1D, 2D and 3D, and photocatalytic studies of these nanomaterials. Before starting her Ph.D. program, she was researcher at Venezuelan Institute for Scientific Research, where developed research in nanomaterials with applications in fields as catalysis, photocatalysis and energy. Currently, she is researcher at Advanced Mining Technology Center associated to research lines for water treatment and desalination processes.

synthesis of biocompatible water-soluble ZnS ..

Zeolitic imidazolate frameworks (ZIFs), a subclass of metal-organic frameworks (MOFs), havebeen recently employed in various fields such as gas separation, catalysis, water purification anddrug delivery.1 Their high importance is due to their chemical and thermal stability in addition tothe flexibility of their design. ZIFs have been synthesized solvothermally or at room temperatureusing organic solvents (e.g. methanol, DMF) or pure water.2 The control of size and morphologyof crystals has been achieved using reverse microemulsion methods, microwave, ultrasoundassistedsyntheses and coordination modulation methods.1-3 Herein, we investigate a newsynthesis method where ZIF crystals are produced using the reaction-diffusion framework (RDF)in a gel medium at room temperature. The method is based on the diffusion of an outer solutionof the organic linker or mixed linkers into an agar gel containing the inner metal ions Zn(II)and/or Co(II) where a precipitation reaction takes place leading to the formation of the ZIFcrystals. A propagating supersaturation wave, initiated at the interface between the outer solutionand the gel matrix leads to a precipitation front endowed with a gradient of crystal sizes rangingbetween 100 nm and 55 μm along the same reaction tube. While the precipitation fronts of ZIF-8 and ZIF-67 travel the same distance for the same initial conditions, ZIF-8 crystals therein areconsistently smaller than the ZIF-67 crystals due to the disparity of their rate of nucleation andgrowth. The effects of temperature, the concentration of the reagents, and the thickness of thegel matrix on the growth of the ZIF crystals are investigated. We also show that by using RDF,we can envisage the formation mechanism of the ZIF crystals, which consists of the aggregationof ZIF nanospheres to form the ZIF-8 dodecahedrons. Moreover, using RDF the formation of asolid-solution ZIF via the incorporation of Co(II) and Zn(II) cations within the same frameworkis achieved in a controlled manner. Finally, we demonstrate that doping ZIF-8 by Co(II)enhances the photodegradation of methylene blue dye under visible light irradiation in theabsence of hydrogen peroxide.

L., Copper(II)-promoted regioselective synthesis of 1,4-disubstituted 1,2,3-triazoles in water.
Efficient Synthesis of Fused 1,2,3-Triazolo-δ-Lactams using Huisgen [3 + 2] Dipolar Cycloaddition

This work reports the synthesis of water soluble and ..

Recently, there has been a great amount of interest in nanoparticles which are able to provide a platform with high contrast for multiple imaging modalities in order to advance the tools available to biomedical researchers and physicians. However, many nanoparticles do not have ideal properties to provide high contrast in different imaging modes. In order to address this, ultrasmall lanthanide doped oxide and fluoride nanoparticles with strong NIR to NIR upconversion fluorescence and a strong magnetic response for magnetic resonance imaging (MRI) have been developed. Specifically, these nanoparticles incorporate gadolinium, dysprosium, or a combination of both into the nano-crystalline host to achieve the magnetic properties. Thulium, erbium, and neodymium codopants provide the strong NIR absorption and emission lines that allow for deeper tissue imaging since near infrared light is not strongly absorbed or scattered by most tissues within this region. This also leads to better image quality and lower necessary excitation intensities. As a part of the one pot synthesis, these nanoparticles are coated with peg, pmao, or d-glucuronic acid to make them water soluble, biocompatible, and bioconjugable due to the available carboxyl or amine groups. Here, the synthesis, morphological characterization, magnetic response, NIR emission, and the quantum yield will be discussed. Cytotoxicity tested through cell viability at varying concentrations of nanoparticles in growth media will also be discussed.

Synthesis and characterization of ionic charged water soluble arginine-based poly ..

Synthesis and properties of biocompatible ..

Thus,the aim of this work was to develop a novel facile route forsynthesising biocompatible QDs employing carbohydrate ligands in aqueouscolloidal chemistry with optical properties tuned by pH.

Synthesis and Properties of a Novel Water-Soluble Lactose-Containing Polymer and Its Cross ..


Functional polymers with a biodegradable backbone, biocompatible degradation products, and controlled degradation profiles are of great promise for biomedical applications. Although providing eminent water-solubility and biocompatibility, the well-studied polyethylene glycol (PEG), and poly(N-(2-hydroxypropyl)methacrylamide (HPMA), lack in degradability, thus leading to accumulation in the body when used as high molecular weight polymers, limiting their applicability to some extent., In addition to polyacetals and polyketals, polyglutamic acid, dendritic polyesters, and recent work about polyphosphoesters, polyphosphazenes certainly represent a promising biodegradable class of polymers for biomedical applications., Because of their unique, degradable backbone, the properties of polyphosphazenes greatly depend on the choice of organic substituents attached to the phosphorus atoms. The major precursor polymer, poly(dichlorophosphazene), can be obtained by thermal ring opening polymerization or living cationic polymerization, followed by macromolecular substitution of the chlorine atoms by a wide range of organic nucleophiles such as amines and alkoxides. Substitution of the polyphosphazene chain with suitable nucleophiles allows the design of poly(organophosphazenes) with versatile properties, multifunctionality, and tunable hydrolytic sensitivity, all of which represent crucial features for polymers used in biomedical applications.