Synthesis and Biological Evaluation of Symmetrical …

Synthesis of indole-2-carboxylic acid derivatives has attracted considerable attention in view of therapeutic applications. In the presented research work, a series of 3-[N,N-Dialkylamine(oxo)acetyl]-1-propyl-1H-indole-2-carboxylic acids was synthesized from 1-Propyl-1H-indole-2-carboxylic acid. The synthesis was carried out by treating 1-Propyl-1H-indole-2-carboxylic acid with oxalyl chloride in dry dichloromethane and condensation of different secondary amines with 1-propyl-1H-indole-2-carbohydrazide forms the titled compounds (OND 1 OND 10). All the synthesized compounds have been characterized by using elemental analysis, FT-IR, 1H NMR, 13C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has been checked on thin layer chromatographic plate and HPLC technique. All the synthesized compounds were screened for their antibacterial activities against Staphylococcus aureus, Staphylococcus pyogenus, Escherichia coli and Pseudomonas aeruginosa and for antifungal activity against Candida albicans and Asperigillus niger. The biological activities of the synthesized compounds have been compared with standard drugs like Ampicillin and Nystatin. The compounds exhibited significant antibacterial and moderate antifungal activities. These compounds can be further exploited to get the potent lead compounds. The detailed synthesis and the antimicrobial screening of the new compounds are reported.

Synthesis and Biological Evaluation of a New Series of …

Synthesis and biological evaluation of novel 1,3,5-triazine derivatives as antimicrobial agents

Synthesis and Biological Evaluation of ..

As the main study in the thesis centers around to incorporate in the s- triazine molecule the 1,5- benzodiazepine nucleus and other moieties and fragments which have the previous history of being biologically active, on this premise that their presence in tandem in a single molecular framework of this nucleus could contribute significantly to the biological efficacy in the resulting materials, in this context it seems necessary in the account to follow to present a brief review of biological aspects and the synthetic aspects of s-Traizines and 1.5-benzodiazepines.

Synthesis and Preliminary Biological Evaluation of ..

s-Triazine are endowed with a wide array of useful pharmacological properties including microbial and anti-inflamatory properties. It was aimed in the present work first to substitute chlorine atoms at different temperature by different neucleophiles. In the synthetic strategies which were envisaged in the present work, the s-triazine molecule has been selected with this idea in mind, that this molecule on one hand was very biologically active and on other hand it could provide a tempelate to hold the three biologically active pharmacophores together in the same molecule.

Synthesis and Biological Evaluation of s-Triazine Substituted Polyamines as Potential New Anti ..
Synthesis and biological evaluation of novel 2,4,6-triazine derivatives as antimicrobial agents.

Design, Synthesis and Biological Evaluation of …

Condensed heterocyclic systems containing imidazole, benzimidazole, oxadiazole, thiadiazole, pyarazole, isoxazole, pyrimidine, diazepine, oxazepine, thiazepine nuclei have attracted the attention of chemists, on account of the significant medicinal properties associated with them. In view of the prodigious range of activities of these compounds, it was considered worthwhile in the present work to undertake investigation on the synthesis of condensed nitrogen-sulfur heterocyclic systems containing above nuclei fused to the s-Triazine neuleus. It was hoped that synthesis of these condensed heteocyclic systems and evaluation of their biological properties would provide a rational approach to the study of structure activity relationship of these molecules.


This process is used for the incorporation of various nucleophiles 47. As a general rule, which varies with the reactivity of the neucleophile chosen, the first substitution occurs at low temperatures (0°C), the second substitution at approximately at room temperature (25-30°C) and the third at elevated temperatures (70-100°C) (Fig. 1). This property allows substitution of three different neucleophiles onto the same triazine core which provides a vast array of possible triazine derivatives. In view of the impressive biological activities shown by cyanuric chloride, it was anticipated that incorporation of pyrimidine molecule to the cyanuric chloride neucleus could form the novel biologically relevant molecules with widespread applications as therapeutics. Claisen-Schmidt condensation and temperature controlled reactions played a crucial role in the establishment of variety of organic molecules of biological importance. Encouraged by the impressive bioactive profiles of s-triazine, together with pyrimidines, it was considered of interest in the present work to explore the possibility of incorporating these moieties together in the same molecule, on the premise that their presence in the same molecular framework could contribute significantly by providing an additive effect on the overall bioefficacy in the resulting materials.

Synthesis and biological evaluation of new ..

In recent years, s-triazine compounds have been studied extensively and have been the subject of many reviews. s-Triazine derivatives possess biological activities such as anti-plasmodial, antitumor, anticancer, herbicidal, anti-inflammatory, antifungal, anti-protozoal, antimalarial, and anti-microbial. It clearly establish that s-triazine framework form an important structural core in many synthetic drugs. In addition to the interest in s-triazine as biologically active materials, these have also found important applications in material sciences.