Synthesis and Biological Evaluation of Symmetrical …
Synthesis of indole-2-carboxylic acid derivatives has attracted considerable attention in view of therapeutic applications. In the presented research work, a series of 3-[N,N-Dialkylamine(oxo)acetyl]-1-propyl-1H-indole-2-carboxylic acids was synthesized from 1-Propyl-1H-indole-2-carboxylic acid. The synthesis was carried out by treating 1-Propyl-1H-indole-2-carboxylic acid with oxalyl chloride in dry dichloromethane and condensation of different secondary amines with 1-propyl-1H-indole-2-carbohydrazide forms the titled compounds (OND 1 OND 10). All the synthesized compounds have been characterized by using elemental analysis, FT-IR, 1H NMR, 13C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the compounds has been checked on thin layer chromatographic plate and HPLC technique. All the synthesized compounds were screened for their antibacterial activities against Staphylococcus aureus, Staphylococcus pyogenus, Escherichia coli and Pseudomonas aeruginosa and for antifungal activity against Candida albicans and Asperigillus niger. The biological activities of the synthesized compounds have been compared with standard drugs like Ampicillin and Nystatin. The compounds exhibited significant antibacterial and moderate antifungal activities. These compounds can be further exploited to get the potent lead compounds. The detailed synthesis and the antimicrobial screening of the new compounds are reported.
Synthesis and Biological Evaluation of a New Series of …
Synthesis and Biological Evaluation of ..
As the main study in the thesis centers around to incorporate in the s- triazine molecule the 1,5- benzodiazepine nucleus and other moieties and fragments which have the previous history of being biologically active, on this premise that their presence in tandem in a single molecular framework of this nucleus could contribute significantly to the biological efficacy in the resulting materials, in this context it seems necessary in the account to follow to present a brief review of biological aspects and the synthetic aspects of s-Traizines and 1.5-benzodiazepines.
Synthesis and Preliminary Biological Evaluation of ..
s-Triazine are endowed with a wide array of useful pharmacological properties including microbial and anti-inflamatory properties. It was aimed in the present work first to substitute chlorine atoms at different temperature by different neucleophiles. In the synthetic strategies which were envisaged in the present work, the s-triazine molecule has been selected with this idea in mind, that this molecule on one hand was very biologically active and on other hand it could provide a tempelate to hold the three biologically active pharmacophores together in the same molecule.