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ABSTRACT: In this article, we synthesize of a novel alginate-based superabsorbent hydrogel via graft copolymerization of 2-acrylamido-2-methylpropanesulfonic acid (AMPS) onto alginate backbones. The polymerization reaction was carried out in an aqueous medium and in the presence of ammonium persulfate (APS) as an initiator and N,N'-methylene bisacrylamide (MBA) as a crosslinker. A proposed mechanism for hydrogel formation was suggested and the structure of the product was established using FTIR and SEM spectroscopies.

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Sadeghi M, Shafiei F, Mohammadinasab E, Mansouri L, Shasavar H. Synthesis of Biodegradable Hydrogel Based on H-alginate-g-poly(AMPS). Biosci Biotechnol Res Asia 2014;11(1). Available from:

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Sadeghi M, Shafiei F, Mohammadinasab E, Mansouri L, Shasavar H. Synthesis of Biodegradable Hydrogel Based on H-alginate-g-poly(AMPS). Biosci Biotechnol Res Asia 2014;11(1)


Synthesis of AM/AMPS/N8AM Tercopolymer in Ionic …

Here we report in vitro ribosomal synthesis of a natural product-like macrocyclic peptide, inspired by the structure of amphotericin B (AmB), an amphiphilic and membrane-interacting antifungal natural product. This AmB-inspired macrocyclic peptide (AmP), one side of which is composed of hydrophobic terpene, and the other side comprises a peptidic chain, was synthesized utilizing flexizyme-assisted in vitro translation via an unusual but successful initiation with a -cysteine derivative. The established method for the synthesis of AmPs is applicable to the generation of a diverse AmP library coupled with an in vitro display format, with the potential to lead to the discovery of artificial bioactive amphiphilic macrocycles.

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