F2-isoprostanes stimulate collagen synthesis in …

Peptides in cosmeceutical skin care products is just expensive hype with no good science based logic. Save your money on those products and just go for:
1. Botox which relaxes hyperdynamic muscles thereby preventing wrinkles and
2. Microneedling treatments to stimulate collagen .
Botox is an inexpensive safe treatment using a very purified pharmaceutical product that actually works. It has been used in medicine for 25 years and is tried and true. Microneedling is a treatment (should be done by a physician) that stimulates collagen and is basic great science. The treatment is called CIT.. Your skin (the epidermis) does not rebuild collagen and is the perfect barrier. It is designed to keep things out to protect the actively growing cells in the lower dermal layer. Peptides in topical skin care products are a complete waste of money. (Trying to get peptide to get into your skin is like trying to get an elephant into a closet)
As for a good daily skin care protocol, stick with the basics ..a good Glycerin based cleanser, vitamin C (water based), glycolic acid , and Retin-A (Vit A) for stimulating cell turnover. AND of course a Elta-MD Zinc Oxide SPF moisturizer to protect your skin every day!

Acetaldehyde and lactate stimulate collagen synthesis …

Supplying these key amino acids in abundance helps stimulate collagen synthesis.

Growth Hormone Stimulates Collagen Synthesis, But …

Chronic pancreatitis is characterized by the presence of chronic inflammatory lesions, the destruction of exocrine parenchyma, and fibrosis. Until now the pathobiochemical and molecular mechanisms resulting in pancreas fibrosis have been controversial and largely unknown. Fibroblast and fibroblast-like cell activation was reported to be a common observation in acute and chronic pancreatitis. It has been suggested that periacinar fibroblast-like cells might play a role in fibrogenesis by synthesizing significant amounts of extracellular matrix (ECM), in particular collagens. Studies from our group have shown that in the cerulein-induced pancreatitis model, proliferation of acinar and centroacinar cells is associated with an increase in mitotic activity of fibroblasts, which is followed by a stimulated synthesis and deposition of collagen. In an earlier study, we illustrated an enhanced expression of transforming growth factor β (TGFβ) during regeneration from cerulein-induced pancreatitis in acinar cells and stromal cells of the rat pancreas, which was followed by stimulated matrix synthesis. Furthermore, we identified and characterized the matrix-producing cell type responsible for pancreas fibrosis, the pancreatic stellate cell (PSC) in mice, rats and humans. Phenotypic transformation of PSCs is characterized by a disappearance of fat droplets and retinyl-esters, development of a prominent endoplasmic reticulum, enhanced expression of smooth muscle α-actin, and increased synthesis of collagen types I and III and fibronectin.

Collagen: How to Boost Collage Production…Naturally

In the present study, we demonstrate that transiently acidified supernatants of LPS stimulated human monocyte-derived macrophages contain TGFβ and stimulated the synthesis of fibronectin and collagen type I in cultured PSCs. These findings suggest that activated macrophages play a critical role in pancreas fibrogenesis by stimulating matrix synthesis of PSCs in a paracrine way.

Furthermore, many ingredients useful in stimulating collagen synthesis are relatively inexpensive and safe.

It’s found in our muscles, bones, skin, and tendon

The benefit of stimulating your own collagen production is that collagen is deposited in an orderly, structured manner and that there is no risk of allergy, immune reaction or injection-induced infection.

Collagen: What is it and what are its uses? - Health News

The effect of glucocorticoids on collagen synthesis was examined in cultured bovine aortic smooth muscle (BASM) cells. BASM cells treated with 0.1 microM dexamethasone during their proliferative phase (11 d) were labeled with [3H]proline for 24 h, and the acid-precipitable material was incubated with bacterial collagenase. Dexamethasone produced an approximate twofold increase in the incorporation of proline into collagenase-digestible protein (CDP) and noncollagen protein (NCP) in the cell layer and medium. The stimulation was present in both primary mass cultures and cloned BASM. An increase in CDP and NCP was detected at 0.1 nM, while maximal stimulation occurred at 0.1 microM. Only cells exposed to dexamethasone during their log phase of growth (1-6 d after plating) showed the increase in CDP and NCP when labeled 11 d after plating. The stimulatory effect was observed in BASM cells treated with the natural bovine glucocorticoid, cortisol, dexamethasone, and testosterone, but was absent in cells treated with aldosterone, corticosterone, cholesterol, 17 beta-estradiol, and progesterone. The increase in CDP and NCP was absent in cells treated with the inactive glucocorticoid, epicortisol, and totally abolished by the antagonist, 17 alpha-hydroxyprogesterone, suggesting that the response was mediated by specific cytoplasmic glucocorticoid receptors. Dexamethasone-treated BASM cells showed a 4.5-fold increase in the specific activity of intracellular proline, which was the result of a twofold increase in the uptake of proline and depletion of the total proline pool. After normalizing for specific activity, dexamethasone produced a 2.4- and 2.8-fold increase in the rate of collagen and NCP synthesis, respectively. Cells treated with dexamethasone secreted 1.7- fold more collagen protein in 24 h compared to control cultures. The BASM cells secreted 70% Type I and 30% Type III collagen into the media as assessed by two-dimensional gel electrophoresis. The ratio of these two types was not altered by dexamethasone. The results of the present study demonstrate that glucocorticoids can act directly on vascular smooth muscle cells to increase the synthesis and secretion of collagen and NCP.

Collagen Capsule from Grass Fed Beef Bone Broth

To demonstrate paracrine stimulation of pancreatic stellate cell proliferation and matrix synthesis by soluble mediators produced by macrophages, macrophage-conditioned media were added to cultured human and rat PSC. The media had been conditioned for 24 hours by unstimulated and LPS-stimulated macrophages in the absence of FCS. Immunofluorescence staining of cell-associated collagen types I and III and fibronectin, Northern blot analyses of collagen type I and fibronectin, and quantitative immunoassay for collagen type I and c-fibronectin in cell culture supernatants were used to examine the effects of macrophage supernatants on ECM synthesis of PSC. The results obtained by the different methods were corresponding. In particular, transiently acidified media from LPS-activated macrophages significantly up-regulated ECM synthesis of cultured PSC.