(R = t-Bu) [] C4H9NaO (MW 96.12)

We present here our results on potassium -butoxide promoted annulation reactions of 2-alkynylphenyl propargyl ethers to give two different types of heterocycles: 3-benzyl-2-alkynylbenzofurans and 12-benzoannulenbenzo[]furans. A series of functionalized 2-alkynylphenyl propargyl ethers were efficiently cyclized by potassium -butoxide to the corresponding products. The optimized reaction conditions tolerated a large variety of functional groups, including electron-rich, electron-poor, and N-heterocyclic substrates. Selective product formation was obtained by controlling the solvent and temperature. When THF was used at room temperature, 3-benzyl-2-alkynylbenzofuran derivatives were exclusively obtained, while the use of DMF at 60 °C gave selectively 12-benzoannulen[]benzofurans.

(R = Et(OCH2CH2)2) [] C6H13NaO3 (MW 156.18)

Potassium t -Butoxide - Paperplane

Sodium Tert.-butoxide - Novasol

Potassium -butoxide in -BuOH or ethereal solvents is not capable of effecting quantitative formation of enolates of unactivated saturated ketones; also, because potassium enolates are subject to rapid proton transfer reactions, their intermolecular alkylations are complicated by equilibration of structurally isomeric enolates, polyalkylation, and aldol condensation reactions. Thus reactions of preformed lithium enolates (generated by deprotonation of ketones with LDA or by indirect procedures) with alkylating agents provide the method of choice for regioselective alkylation of unsymmetrical ketones., However, as illustrated in eqs 3 and 4,, ketones capable of forming only a single enolate, such as symmetrical cyclic ketones and those containing -methylene blocking groups,

Sodium tert-butoxide CAS#: 865-48-5

Sodium tert-butoxide is used as a strong base and a non-nucleophilic base. In organic synthesis, it serves as an intermediate in various reactions like condensation, rearrangement and ring-opening. Further, it finds use in agrochemicals, pharmaceuticals, colorants, aroma chemicals, detergents and biodiesel. It acts as a catalyst in polymerization and isomerization reactions.

Caine, D. 2001. Potassium -Butoxide–Dimethyl Sulfoxide. e-EROS Encyclopedia of Reagents for Organic Synthesis. .
Caubére, P. 2001. Sodium Amide–Sodium -Butoxide. e-EROS Encyclopedia of Reagents for Organic Synthesis. .

Potassium t-Butoxide–Dimethyl Sulfoxide

Handling, Storage, and Precautions: see Potassium tert-Butoxide and Dimethyl Sulfoxide. Store over 4 molecular sieves.b Use in a fume hood.

The tertiary alcoholate (butoxide) serves to complex the lithium ion, which breaks the butyllithium clusters.

Sodium tert-butoxide supplier distributor- CAS 865-48-5

Potassium tert-butoxide is used as a strong non-nucleophilic base in organic chemistry. It plays an active role in dehydrohalogenation reactions. It is also useful for greener amidation of esters. It serves as an intermediate in Mizoroki-Heck-type reactions. Furthermore, it is used as an initiator in anionic polymerization of carbazolyl-substituted oxiranes. It catalyzes the reaction of hydrosilanes and heterocyclic compounds to give the silyl derivatives with evolution of hydrogen.

exemplary runs of lithium tert-butoxide employing low sodium ..

Midya, G. C.; Kapat, A.; Maiti, S.; Dash, J. Transition-Metal-Free Hydration of Nitriles Using Potassium tert-Butoxide under Anhydrous Conditions. J. Org. Chem. 2015, 80 (8), 4148-4151.