T1 - Signaling Endosome Hypothesis

A generation ago, the immunoglobulin intramolecular signaling, or allosteric, hypothesis was abandoned in favor of the associative hypothesis, which posited that Fc receptor crosslinking produced the increased affinity of antigen–antibody complexes. This essay argues that there is sufficient evidence to resuscitate the allosteric hypothesis, at least for some antibodies.

T1 - Modeling the signaling endosome hypothesis

KW - Signaling endosome hypothesis

favors the dividend signaling hypothesis over the alternatives.

We therefore adopt a more formal proce-Under the hypothesis that the evolution of dure for testing the differences between the the excess-return relationship is driven by various subregimes. This procedure recog-changes in the tax regime, we would expect nizes the possibility that, in general, a to obtain the following results: change in dividend taxation may shift the entire signaling equilibrium, thereby poten-Test 1: reject equality of coefficients; tially altering the coefficients of all the ex-Test 2: do not reject equality of coefficients; planatory variables included in Table 3." Test 3: reject equality of coefficients.


Another potential objection to this analy- sis is that variation in tax rates is only pre- sent across years, and not across firms. Since THETA, tends to decline over the sample period, our effort to measure tax effects could conceivably pick up some spurious trend. We are inclined to doubt this hypoth- esis for two reasons. First, the evidence on tax effects is corroborated by evidence on bond ratings, and bond ratings vary consid- erably across firms. Second, the most plausi- ble explanation for a spurious trend sug- gests that our estimates should be biased against the dividend signaling hypothesis. During the 1980's, domestic firms faced in- creasing levels of competition from abroad. Casual evidence suggests that, as a result, investors became more sensitive to manage- rial inefficiency. Thus, in the absence of signaling, one would have expected to ob- serve an increase in the bang-for-the-buck during the 1980's.

Signaling New Effect From Europe | Dividend | Hypothesis
Modeling the signaling endosome hypothesis: Why a …

A Tax-Based Test of the Dividend Signaling Hypothesis

Our long-term goal is to understand the role of the pulmonary IIR in airway disease. Project 1 (P1) seeks to understand the mechanism(s) by which ROS modulate innate signaling in the epithelial cell. We will test the hypothesis that ROS control innate inflammatory and antiviral pathways by promoting the activation of NF-lB/RelA and IRF3 in the airway epithelium. We will investigate key aspects of this central hypothesis by pursuing three Specific Aims, to:

The authors propose and implement a new test of the dividend signaling hypothesis

The synaptic Wnt signaling hypothesis, Synapse | …

We examine corporate bond issues around stock splits and find a significant decline in the bond yield spread following stock splits, supporting the signaling hypothesis.

Neural Development, Cell-Cell Signaling, and the “Two-Hit” Hypothesis of Schizophrenia


Third, note that THETA, is inversely related to the effective tax rate on dividends (mj,).It is important to bear this fact in mind when evaluating our empirical results. Under the signaling hypothesis, an increase in THETA, should decrease the bang-for- the-buck; the alternative hypotheses imply that an increase in THETA, should increase the bang-for-the-buck.