Depression: Death to the serotonin hypothesis ..
and heard that the serotonin hypothesis of depression …
Historically, antidepressants alone have been used more often than either psychotherapy alone, or combination treatment for numerous reasons (Simon & Cienchanowski, 2015) including:
The Neurotransmitter Hypothesis of Schizophrenia - …
People not suffering from depression have a balance in degradation and regeneration processes in the brain. The degradation process refers to the breaking down of nerve cells, while regeneration refers to the formation of nerve cells (1). Depressed patients show greater activity in the degradation system, which explains Videbech’s findings that brain structures are reduced in patients with depression. The location of reduction cited by Videbech is the hippocampus, the structure of the brain responsible for the storage and retrieval of memories. Hippocampal reduction explains the common symptom of memory problems in patients with depression. With antidepressant use, and hence a return of neurogenesis, memory problems and depressive symptoms are reduced. Meaning, boosting neurogenesis results in a returned balance between the degradation and regeneration processes. (2)
of how the ‘low serotonin hypothesis’ came to be ..
Compared to 1st generation antidepressants (TCAa & MAOIs), SSRIs have “relatively benign” side effects due to their selectivity in affecting serotonin. For most patients, the most bothersome side effects include (Hu et al, 2004; Hirsch & Birnbaum, 2016). In order of incidence, the most commonly reported side effects include:
that increases the risk of depression
Metabolism and elimination of SSRIs is primarily due to hepatic (P450) metabolism. The elimination half-life for most SSRIs is 20-30 hrs. Fluoxetine metabolism yields an active metabolite (norfluoxetine) that has a half-life of 4-16 days. When switching from fluoxetine to another antidepressant, doses of the new agent should typically be initially reduced to account for the long half-life of norfluoxetine when cross-tapering from one agent to another (Hirsch & Birnbaum, 2016b).