Inorganic disinfectant by-products

The goal is to use these probes to control function of RNA inbiological systems.



We are currently using small aromatic molecules that are not expected to disrupt structural aspects of the unmodified RNA, i.e., thiophene, furan, pyrrole, or pyridyl.We rely on the use of organic synthesis and photochemistry along with various biochemical and biophysical techniques to achieve our goals.

Formation of organohalogen disinfectant by-products

Trimercaptotriazine (TMT)Highly effective scavenger of organometallic species.

Chlorine organohalogen by-products

1.5.2 Characterization of exposure 1.5.2.1 Occurrence of disinfectants and disinfectant by-products Disinfectant doses of several milligrams per litre are typically employed, corresponding to doses necessary to inactivate microorganisms (primary disinfection) or doses necessary to maintain a residual in the distribution system (secondary disinfection).

Chloramine organohalogen by-products

1.2 Kinetics and metabolism in laboratory animals and humans 1.2.1 Disinfectants Residual disinfectants are reactive chemicals that will react with organic compounds found in saliva and stomach content, resulting in the formation of by-products.

Physical and chemical properties of common disinfectants and inorganic disinfectant by-products

Introduction / Quality Control / Organic Synthesis / Scavengers ..

Evidence was presented suggesting that some of the carbon monoxide arose from the oxidative metabolism of bromoform to a dibromocarbonyl and subsequent reactions with GSH.

In organosulfur compound: Reactions …organic synthesis

Bromoform (and organic metabolite) elimination via exhaled breath was greater than that for all other THMs in the rat (67%), but less than that for all other THMs in the mouse (6%).

SCAVENGER strategies in organic synthesis - Part One

Thus, simply on the basis of considerations of target organ dosimetry, the effects of DCA would be predicted to increase sharply at chronic dosing levels that approach or exceed 30 mg/kg of body weight per day rather than being simple linear functions of dose.

in principle, as scavengers as well as for organic synthesis5.

The pattern of distribution and elimination of DBCM was very similar to that observed with BDCM: rats expired more of the dose than mice as a trapped organic component presumed to be the parent compound (48% vs.

Formation of non-halogenated organic disinfectant by-products

Chlorine dioxide organic by-products

However, the LD50 for 1,3-DCPN was stated to be 25 mg/kg of body weight, indicating that the liver was probably not the critical target organ for this compound, at least with acute treatment.

Basmati) and enrichment in soil fertility applied with an organic matrix entrapped urea

Feng TH (1966) Behaviour of organic chloramines in disinfection.

NOM provides the precursor material from which organic DBPs are formed; consequently, increasing concentrations of NOM lead to increasing concentrations of by-products.

A carcinogenicity study in rats showed increased tumour frequencies in several organs.

Inorganic compounds and radicals.

The most common alternative mode of action would be evidence that carcinogenic doses of DCA induce cytotoxic damage in the target organ, which leads to reparative hyperplasia.