Role of the macula densa in renin synthesis and secretion
The role of mRNA in protein synthesis.
We demonstrate that inhibition of mTORC1 increases NT mRNA and protein content as well as NT promoter activity, indicating that mTORC1 plays an inhibitory role in the transcriptional regulation of the NT gene in enteroendocrine-like cells.
What is the role of DNA in protein synthesis? - Quora
Our findings identify a novel mechanism for mTOR regulation of intestinal hormone secretion via downregulation of gene expression and protein synthesis.
Overview of the Secretory Pathway - Molecular Cell …
Our results support the occurrence of the following chain of events in VSMC from LZR: (i) oleic acid activates PKC-beta; (ii) PKC-beta is involved in the oleic acid-induced increase of oxidative stress, since it is impaired by LY379196; (iii) oxidative stress is involved in the activation of ERK-1/2, since it is impaired by apocynin and rotenone; (iv) ERK-1/2 play a crucial role in the increase of VEGF-A synthesis and secretion, since these effects are impaired by PD98059.
Section 17.3 Overview of the Secretory Pathway
Thus, our data suggest that the acute increase of ROS induced by oleic acid plays a crucial role in the molecular mechanisms involved in VEGF synthesis and secretion in VSMC from LZR, whereas the chronically high oxidative stress impairs the ability of VSMC from OZR to respond to oleic acid with a further increase of ROS and the consequent activation of the signalling pathways involved, even if the baseline, constitutive VEGF synthesis is unaffected.
pathway of protein synthesis and ..
The present study shows that oleic acid increases in a concentration- and time-dependent manner VEGF-A mRNA expression, synthesis and secretion in VSMC from LZR with a mechanism mediated by a complex network of intracellular signalling molecules, involving Akt, mTOR, ERK-1/2, PKC-beta, NADPH oxidase and the mitochondrial electron transport chain complex. We also demonstrated the ability of oleic acid to activate all the above-mentioned signalling pathways and to increase oxidative stress.