Statin drug and coenzyme q10 deficiency

The addition of PEL increases absorption of CoQ-10 in the blood, so that mitochondrial (Election Transport System) energy production of ATP is maximized.

What Is The Role Of Coenzyme Q10 In Atp Synthesis | IMS …

And unlike CoEnzyme Q, which is synthesizedin the cell, Vitamin E must be obtained from the diet.

What is the role of coenzyme Q10 in ATP synthase

Over the past 25 years, the vitamin-like substance Coenzyme Q10–synthesized in the liver and other cells from lower number CoQs, and ingested in many foods5–has been reported to be ef-fective in reducing various cancers and metastases, even in patients for whom all conventional treatments had failed.6,7 Some of these are alive and well 15 years later without any trace of cancers. AIDS patients showed striking response to therapy with CoQ10; the HIV virus appears to induce a deficiency of CoQ10.8

Explain the role to coenzyme Q10 in atp synthase?

Although the genes encoding for the CoQ10 ( )biosynthetic enzymes have been identified in bacteria and yeast, there is still only limited information about these synthetic enzymes in vertebrates.
The rate-limiting enzyme for the biosynthesis of CoQ10 is the enzyme that catalyzes the condensation of the polyisoprenoid chain with the benzoquinone ring.
So far, the mitochondrial enzyme has been considered the only prenyltransferase able to catalyze this reaction.

Humans haveonly one type of CoQ, which has 10 repeated units and is therefore calledCoenzyme Q10.

Ever since the discovery of coenzyme Q10 in ..

( ) contains an UbiA prenyltransferase domain also present in vertebrate
Although encodes a mitochondrial prenyltransferase, this new enzyme resides in the Golgi compartment where it produces CoQ10. While the presence of CoQ10 in nonmitochondrial membranes was previously explained by the existence of specific mechanisms for its redistribution within the cell, now formally studies demonstrate that CoQ10 are synthetized in the Golgi compartment.
In favor of these hypothesis of a Golgi-synthetized CoQ10, it has been reported that and which are critical enzymes for CoQ10 maturation, are also localized in the Golgi compartment. ( )

However, the effect of MPP+ and MPTP on coenzyme Q is not clearly understood.

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Mitochondrion disease
Int J Biochem Cell Biol. 2014 Feb 2. Coenzyme Q10 as a therapy for mitochondrial disease. Treatment of mitochondrial respiratory chain (MRC) disorders is extremely difficult, however, coenzyme Q10 and its synthetic analogues are the only agents which have shown some therapeutic benefit to patients. It serves as an electron carrier in the MRC as well as functioning as a potent lipid soluble antioxidant.

Omega-3 with CoQ10 from Thorne Research is a healthful combination of omega-3 fatty acids and coenzyme Q10

This process is part of ATP synthesis, or energy production

This study demonstrated that MPP+/MPTP significantly affected the coenzyme Q content in the SH-SY5Y and NG-108 cells and in the mouse nigrostriatal tract.

Optimal electron transport to generate ATP depends upon there being optimallevels of CoQ10 in the mitochondrial membrane.

The Role of Coenzyme Q10 in Statin ..

Since is localized in the Golgi compartment, this enzyme might be a nonmitochondrial CoQ10 prenyltransferase. To test this, laboratories performed subcellular fractionation experiments on human ECs and detected only in Golgi compartments and not in mitochondria.
Studies about de novo CoQ10 synthesis in these subcellular fractions by incubating ECs with the hydroxy-4-benzoic acid- 13 C 6 precursor and observed a decrease in CoQ10- 13 C 6
production in Golgi compartments compared to mitochondrial fractions when expression is reduced.
These data indicate that is a CoQ10 biosynthetic enzyme located in the Golgi membrane compartment where large amounts of cellular CoQ10 are normally synthesized.