What Is The Role Of Coenzyme Q10 In Atp Synthesis | IMS …
What is the role of coenzyme Q10 in ATP synthase
Over the past 25 years, the vitamin-like substance Coenzyme Q10–synthesized in the liver and other cells from lower number CoQs, and ingested in many foods5–has been reported to be ef-fective in reducing various cancers and metastases, even in patients for whom all conventional treatments had failed.6,7 Some of these are alive and well 15 years later without any trace of cancers. AIDS patients showed striking response to therapy with CoQ10; the HIV virus appears to induce a deficiency of CoQ10.8
Explain the role to coenzyme Q10 in atp synthase?
Although the genes encoding for the CoQ10 ( )biosynthetic enzymes have been identified in bacteria and yeast, there is still only limited information about these synthetic enzymes in vertebrates.
The rate-limiting enzyme for the biosynthesis of CoQ10 is the enzyme that catalyzes the condensation of the polyisoprenoid chain with the benzoquinone ring.
So far, the mitochondrial enzyme has been considered the only prenyltransferase able to catalyze this reaction.
Ever since the discovery of coenzyme Q10 in ..
( ) contains an UbiA prenyltransferase domain also present in vertebrate
Although encodes a mitochondrial prenyltransferase, this new enzyme resides in the Golgi compartment where it produces CoQ10. While the presence of CoQ10 in nonmitochondrial membranes was previously explained by the existence of specific mechanisms for its redistribution within the cell, now formally studies demonstrate that CoQ10 are synthetized in the Golgi compartment.
In favor of these hypothesis of a Golgi-synthetized CoQ10, it has been reported that and which are critical enzymes for CoQ10 maturation, are also localized in the Golgi compartment. ( )