Major health concerns: platelet function abnormalities (rare).

Novel 4-quinolone-3-carboxylates 6,7 and 4-quinolone-3-carboxylic acids 8-11 were synthesized from 4-hydroxyquinoline-3-carboxylates. Ethyl 1-[1-ethoxycarbonyl-2-(4-pyridyl)vinyl]-6-fluoro-4-oxoquinoline-3-carboxylate 7a was found to show antimalarial activity from the screening data.

Major health concerns: erythromycin estolate is hepatotoxic.

Macrolides are bacteriostatic drugs that inhibit protein synthesis by targeting the 50S subunit.

Major health concerns: ototoxicity, nephrotoxicity.

Plasmocin™ is also active at low concentrations on a broad range of Gram positive and Gram negative bacteria that are otherwise resistant to the mixture of streptomycin and penicillin, and exhibits no toxicity in eukaryotic cells.

Last updated: September 12, 2017

Many cell lines infected by mycoplasmas have been successfully treated with Plasmocin™, including embryonic stem cells, hybridomas and retrovirus packaging cells.

Fluoroquinolones directly inhibit the bacterial nucleic acid synthesis.

KW - Research Support, Non-U.S. Gov't

Citation data is made available by participants in Cited-by Linking service. For a more comprehensive list of citations to this article, users are encouraged to perform a search in.

JO - Bioorganic and Medicinal Chemistry Letters

Citation data is made available by participants in Cited-by Linking service. For a more comprehensive list of citations to this article, users are encouraged to perform a search in.

JF - Bioorganic and Medicinal Chemistry Letters

Citation data is made available by participants in Cited-by Linking service. For a more comprehensive list of citations to this article, users are encouraged to perform a search in.

Cookies are used by this site. To decline or learn more, visit our

Citation data is made available by participants in Cited-by Linking service. For a more comprehensive list of citations to this article, users are encouraged to perform a search in.

Congratulations to the winners of the 2016 Nobel Prize in Chemistry

Pale Yellow solid; m.p. 194-195 oC; Yield 90%; IR (KBr) νmax (cm-1): 3105 (NH), 2960 (CH), 1707, 1620 (C=O). 1H NMR (CDCl3) δ ppm: 1.12, 1.80 (both s, 3H each, C(7) (CH3)2); 2.36 (m, 2H, CH2); 2.47 (m, 2H, CH2); 2.68 (m, 2H, CH2); 4.38 (d, 1H, H(4)); 7.60-8.09 (m, 4H, Ar-H) and 8.36 (s, 1H, NH). 13C NMR (CDCl3) δ ppm: 27.80, 29.30, 33.08, 33.97, 37.80, 41.29, 50.69, 113.68, 121.64, 122.41, 130.09, 133.61, 151.39, 171.31and 195.52.

T2 - Bioorganic and Medicinal Chemistry Letters

White solid; m.p. 201-203 oC; Yield 67%; IR (KBr) νmax (cm-1): 3219 (NH), 2960 (CH), 1695, 1645 (C=O). 1H NMR (CDCl3) δ ppm: 0.92, 1.03 (both s, 3H each, C (7) (CH3)2); 2.21 (s, 3H, C(4)-p-CH3-Phenyl); 2.27 (m, 2H, CH2); 2.39 (m, 2H, CH2); 2.87(m. 2H, CH2); 4.31(d, 1H, H(4)); 7.03-7.25 (m, 4H, C6H5) and 8.80 (s, 1H, NH). 13C NMR (CDCl3) δ ppm: 27.79, 29.04, 33.42, 32.83, 37.97, 41.12, 50.71, 115.03, 126.05, 129.47, 136.48, 139.12, 150.13, 172.23 and 195.49.

1155 Sixteenth Street N.W.Washington, DC 20036

Citation data is made available by participants in Cited-by Linking service. For a more comprehensive list of citations to this article, users are encouraged to perform a search in.