Pyridoxal phosphate: biosynthesis and catabolism.
Biosynthesis Of Amino Acids - PEOI
In addition to their role as the building blocks of proteins,amino acids are precursors of many specialized biomolecules,including hormones, coenzymes, nucleotides,alkaloids, cell wall polymers, porphyrins, antibiotics,pigments, and neurotransmitters. We describe here thepathways to a number of these amino acid derivatives.
Pyridoxyl phosphate | CAS#54-47-7 | purinergic P2 …
FIGURE 1510 Biosynthesis of δ-aminolevulinate. (a) In mammalsand other higher eukaryotes, δ-aminolevulinate is synthesized fromglycine and succinyl-CoA. The atoms furnished by glycine are shownin red. (b) In bacteria and plants, the precursor of δ-aminolevulinateis glutamate. (c) Biosynthesis of heme from δ-aminolevulinate.
Nitric Oxide Synthesis and Function
FIGURE 156 Tryptophan synthase reaction. This enzyme catalyzes amultistep reaction with several types of chemical rearrangements.
1) An aldol cleavage produces indole and glyceraldehyde 3-phosphate; thisreaction does not require PLP.
2) Dehydration of serine forms a PLP-aminoacrylate intermediate.
3) and 4) PLP-aminoacrylate condenses with indole.
5) the product is hydrolyzed to release tryptophan.
These PLP-facilitated transformations occur at the β carbon (C-3) of the aminoacid. The β carbon of serine is attached to the indole ring system. TryptophanSynthase Mechanism.
Semester Paper | Biochemistry for Medics – Lecture Notes
Vol. 7: COFACTORS
Edited by Tadhg Begley
vitamins and enzymatic co-factors, including riboflavin biosynthesis, genomics, and enzymology of NAD biosynthesis; pyridoxal phosphate biosynthesis; cofactor catabolism