Where to buy Pyridine-4-carboxaldehyde

Product name:
CAS:
872-85-5
Molecular Formula: C6H5NO
Molecular Weight: 107.11
Product description:Yellowish oily liquid. Boiling point: 82-83 ℃ (2.13 kPa), relative density 1.122, the refractive index of 1.5352 (25 ℃). Flash point 54 ℃. Soluble in water and ethyl ether.4 - methyl pyridine by oxidation. 4 - methyl pyridine and air mixture, through the temperature to 400 ℃ of vanadium - molybdenum catalyst layer, oxide generated pyridine - 4 - formaldehyde.1, mild alzheimer's disease in synthetic treatment of donepezil HCL intermediates 2, the basic raw material in organic synthesis.

Alfa Aesar™ Pyridine-4-carboxaldehyde, 97% - Fisher Sci

Pyridine-2-carboxaldehyde, CAS Number: 26445-06-7
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2-(Hydroxymethyl)-pyridine-4-carboxaldehyde - Synchem

A series of 3- and 5-alkylamino derivatives, as well as other structurally modified analogues of pyridine-2-carboxaldehyde thiosemicarbazone, have been synthesized and evaluated as inhibitors of CDP reductase activity and for their cytotoxicity in vitro and antineoplastic activity in vivo against the L1210 leukemia. Alkylation of 3- and 5-amino-2-(1,3-dioxolan-2-yl)pyridines (1, 2) resulted in corresponding 3-methylamino, 5-methylamino, 3-allylamino, 5-ethylamino, 5-allylamino, 5-propylamino, and 5-butylamino derivatives (5, 6, and 1115), which were then condensed with thiosemicarbazide to yield the respective thiosemicarbazones (7, 8, and 1620). Oxidation of 3,5-dinitro-2-methylpyridine (21) with selenium dioxide, followed by treatment with ethylene glycol and -toluenesulfonic acid, produced the cyclic ethylene acetal, 23. Oxidation of 2-(1,3-dioxolan-2-yl)-4-methyl-5-nitropyridine (26) with selenium dioxide, followed by sequential treatment with sodium borohydride, methanesulfonyl chloride, and morpholine afforded the morpholinomethyl derivative 30. Catalytic hydrogenation of 23 and 30 with Pd/C yielded the corresponding amino derivatives 24 and 31. Catalytic hydrogenation of 5-cyano-2-methylpyridine (33) with Raney nickel, followed by treatment with acetic anhydride, gave the amide derivative 35. -Oxidation of 35, followed by rearrangement with acetic anhydride, produced the acetate derivative, 5-[(acetylamino)methyl]-2-(acetoxymethyl)pyridine (37). Repetition of the -oxidation and rearrangement procedures with compound 37 yielded the diacetate derivative 39. Condensation of compounds 24, 31, and 39 with thiosemicarbazide afforded the respective 3,5-diaminopyridine-, 4-(4-morpholinylmethyl)-5-aminopyridine-, and 5-(aminomethyl)pyridine-2-carboxaldehyde thiosemicarbazones (25, 32, and 40). The most biologically active compounds synthesized were the 5-(methylamino)-, 5-(ethylamino)-, and 5-(allylamino)pyridine-2-carboxaldehyde thiosemicarbazones (8, 17, and 18), which were potent inhibitors of ribonucleotide reductase activity with corresponding IC50 values of 1.3, 1.0, and 1.4 μM and which produced significant prolongation of the survival time of L1210 leukemia-bearing mice, with corresponding optimum % T/C values of 223, 204, and 215 being obtained when administered twice daily for six consecutive days at dosages of 60, 80, and 80 mg/kg, respectively.

2-(Trifluoromethyl)-pyridine-4-carboxaldehyde - Synchem



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Alfa Aesar Pyridine-4-carboxaldehyde, 97% 100g
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1H-Pyrrolo[2,3-b]pyridine-4-carboxaldehyde, ..

Sigma-Aldrich Online Catalog Product List: C4 to C7

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