Evidence in favor of a protein-only hypothesis include:
Beyond the protein-only hypothesis: A ..
The concept of signal‐mediated targeting of proteins was expanded into a generalised hypothesis of protein topogenesis by Günter Blobel in 1980.
protein only hypothesis translation in English-French dictionary
A breakthrough occurred when researchers discovered that the infectious agent consisted mainly of a specific protein, which Prusiner called PrP (an abbreviation for "prion protein"). This protein is found in the of normal (its precise function is not known), but an altered shape distinguished the infectious agent. The normal one is called PrPC, while the infectious one is called PrPSC (the 'C' refers to 'cellular' PrP, while the 'SC' refers to '', a prion disease occurring in sheep). It is hypothesized that the distorted protein somehow induces normal to also become distorted, producing a that both propagates the disease and generates new infectious material. Since the original hypothesis was proposed, a for the PrP protein has been isolated (the PRNP gene), several that cause the variant shape have been identified and successfully cloned, and studies using genetically altered mice have bolstered the prion hypothesis. In 2004, researchers succeeded in infecting mice with artifical prions composed entirely of synthetic PrPSC protein, confirming the "protein only" model for prion disease.