Practical Synthesis of a Novel and Highly ..

Ideally, the simple synthesis will permit the development of analogs that can address such side effects as well as efficacy issues, Cox says. Should an analog reach the market, he adds, "I hope that the intellectual heritage of prostratin, which began with Samoan healers, will be recognized by the negotiation of a fair and equitable return with the Samoan people."

The elegant synthesis of prostratin and structural analogs in gram ..

Practical Synthesis of Prostratin, DPP, and Their Analogs, Adjuvant Leads Against Latent HIV
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Practical synthesis of prostratin, DPP, and their ..

Here we report a practical synthesis of prostratin and DPPstarting from phorbol or crotophorbolone, agents readily available fromrenewable sources, including a biodiesel candidate.

synthesis of prostratin from ..

“Practical Synthesis of Prostratin, DPP, and Their Analogs, Adjuvant Leads Against Latent HIV.” Science, 2008, 320 (5876), 649-652.

Practical synthesis of prostratin, DPP, and their analogs, adjuvant leads against latent HIV
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The lab's work may give doctors a practical ..

Wender, who published the first practical synthesis of prostratin and its analogs in 2008, had set out to make a simpler, more effective synthetic analog of bryostatin.

Stanford chemists synthesize compound that flushes …

"It's fantastic to have not only a practical synthesis of prostratin but also a simple one," says biologist , director of the Institute of Ethnomedicine, who learned of prostratin's antiviral activity from Samoan healers in 1984 and introduced the compound to Western scientists. "But this is more than a nice synthesis; it could change the trajectory of HIV drug development."

doctors a practical way to flush ..

More importantly, we could in principle design more effective agents.

We have established a program that addresses the prostratin supply problem, has produced the first synthetic source of prostratin and is directed at the optimization of the therapeutic properties of prostratin through function oriented analog design and synthesis.

Stereocontrol in the Synthesis of Bryostatin ..

E.; Clarke, M.; Horan, J.; Kan, C.; Lacote, E.; Lippa, Nell, P.; Turner, T.“The Practical Synthesis of a Novel and Highly Potent Analog of Bryostatin” J.

Giving Samoan Healers Credit for Prostratin | Science

Warrington, "Practical Synthesis of Prostratin, DPP, and their Analog, Adjuvant Against Latent HIV", Science, 2008, 320, 649-652.

Bryologs more potent than prostratin in treating HIV

The flexible synthesis permits replacement of prostratin's acetyl group and other modifications, thereby "opening access to a variety of new analogs," Wender says.