Phosphatidic Acid Synthesis in Bacteria - ResearchGate

purified a phospholipid (phosphatidylcholine) from egg yolk onan alumina column ().

Baer E described the synthesis of phosphatidic acid by treatment ofdiacylglycerol with diphenylchlorophosphate and removal of the phenyl group bycatalytic reduction ().

Hofman K et al.

Phosphatidic acid synthesis in the heart

T1 - Lipid sensing by mTOR complexes via de novo synthesis of phosphatidic acid

Phosphatidic acid synthesis in bacteria - DeepDyve

AB - mTOR, the mammalian target of rapamycin, integrates growth factor and nutrient signals to promote a transformation from catabolic to anabolic metabolism, cell growth, and cell cycle progression. Phosphatidic acid (PA) interacts with the FK506-binding protein-12-rapamycin-binding (FRB) domain of mTOR, which stabilizes both mTOR complexes: mTORC1 and mTORC2. We report here that mTORC1 and mTORC2 are activated in response to exogenously supplied fatty acids via the de novo synthesis of PA, a central metabolite for membrane phospholipid biosynthesis. We examined the impact of exogenously supplied fatty acids on mTOR in KRas-driven cancer cells, which are programmed to utilize exogenous lipids. The induction of mTOR by oleic acid was dependent upon the enzymes responsible for de novo synthesis of PA. Suppression of the de novo synthesis of PA resulted in G1 cell cycle arrest. Although it has long been appreciated that mTOR is a sensor of amino acids and glucose, this study reveals that mTOR also senses the presence of lipids via production of PA.

Phosphatidic acid synthesis in mitochondria. …

N2 - mTOR, the mammalian target of rapamycin, integrates growth factor and nutrient signals to promote a transformation from catabolic to anabolic metabolism, cell growth, and cell cycle progression. Phosphatidic acid (PA) interacts with the FK506-binding protein-12-rapamycin-binding (FRB) domain of mTOR, which stabilizes both mTOR complexes: mTORC1 and mTORC2. We report here that mTORC1 and mTORC2 are activated in response to exogenously supplied fatty acids via the de novo synthesis of PA, a central metabolite for membrane phospholipid biosynthesis. We examined the impact of exogenously supplied fatty acids on mTOR in KRas-driven cancer cells, which are programmed to utilize exogenous lipids. The induction of mTOR by oleic acid was dependent upon the enzymes responsible for de novo synthesis of PA. Suppression of the de novo synthesis of PA resulted in G1 cell cycle arrest. Although it has long been appreciated that mTOR is a sensor of amino acids and glucose, this study reveals that mTOR also senses the presence of lipids via production of PA.

Accumulation of free fatty acids of abnormal length during inhibition of phospholipid synthesis
obtained evidence that fatty acids aresynthesized in mice and rats by condensation of acetic acid ().

Phosphatidic acid synthesis essay - LUUWHC

first demonstrates the reliability of a new stratigraphictechnique for climatic assessment utilizing the relative abundance of two C37alkenones in marine sediments ().

First demonstration of a specific receptor-mediated release of 20:4n-6 and22:6n-3 from plasmalogen phospholipids ().

Evidence is given that phosphatidic acid is a lipid second messenger with growthfactor-like properties, stimulating the breakdown of phosphoinositides andcalcium release ().

Demonstration of an inhibition of protein kinase C by sphingosine whichsuggested an important role for that lipid in the regulation of the signaltransduction pathways (, ).

First clear demonstration of a formation of diacylglycerol as second messengerfrom phosphatidylcholine in hormone-stimulated cells ().

Abscisic acid, one of the most important phytohormones, has been shown to bepresent in the central nervous system of pigs and rats ().

After the discovery of 20:5n-3 in a marine bacterium (Johns RB et al., 1977), a study on 11 piezophilic bacteria (from 1200 to 10 476 m of sea depth) revealed they produced EPA (20:5n-3) and DHA (22:6n-3) in increasing proportion oftotal fatty acids when pressure increased ().

Phosphatidic Acid Synthesis in Escherichia coli

described the mechanism of the regulation of lipogenesis by fatty acids in measuring the rate of synthesis of fatty acid synthase in mouse liver ().

Holman RT et al.

Phosphatidic Acid Synthesis in Castor Bean Endosperm

demonstrated that nearly allphosphatidylserine and a minimum of 70% of phosphatidylethanolamine is on theinside surface of the human erythrocyte membrane, thus "presenting a strongevidence for an asymmetric arrangement of phospholipids" ().

First demonstration of an inhibition of sterol biosynthesis (HMG-CoA reductaseactivity) by oxygenated derivatives of cholesterol in cultured mammalian cells ().

For the first time, the existence of polyunsaturated fatty acids was reported inmarine bacteria ().